An alpha-helical peptidomimetic scaffold for dynamic combinatorial library formation

Busschaert, Nathalie, Thompson, Sam and Hamilton, Andrew D. (2017) An alpha-helical peptidomimetic scaffold for dynamic combinatorial library formation. Chemical Communications, 53 (2), 313-316. (doi:10.1039/C6CC07787K).

Record type: Article

Abstract

A novel oligobenzamide-based alpha-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an alpha-helix, and to allow for the facile creation of dynamic libraries.

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Accepted/In Press date: 7 November 2016

e-pub ahead of print date: 7 November 2016

Published date: 7 January 2017

Organisations: Chemistry

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Identifiers

Local EPrints ID: 403565

URI: http://eprints.soton.ac.uk/id/eprint/403565

DOI: doi:10.1039/C6CC07787K

ISSN: 1359-7345

PURE UUID: 70b604f6-0170-4783-b2fc-d5cbfa27ac1a

ORCID for Sam Thompson:

orcid.org/0000-0001-6267-5693

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Date deposited: 06 Dec 2016 15:44

Last modified: 15 Mar 2024 03:54

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Contributors

Author: Nathalie Busschaert

Author: Sam Thompson

Author: Andrew D. Hamilton

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