The University of Southampton
University of Southampton Institutional Repository

An alpha-helical peptidomimetic scaffold for dynamic combinatorial library formation

An alpha-helical peptidomimetic scaffold for dynamic combinatorial library formation
An alpha-helical peptidomimetic scaffold for dynamic combinatorial library formation
A novel oligobenzamide-based alpha-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an alpha-helix, and to allow for the facile creation of dynamic libraries.
1359-7345
313-316
Busschaert, Nathalie
bf307f09-0a86-4a03-afd8-4b0a59a8f72b
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Busschaert, Nathalie
bf307f09-0a86-4a03-afd8-4b0a59a8f72b
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd

Busschaert, Nathalie, Thompson, Sam and Hamilton, Andrew D. (2017) An alpha-helical peptidomimetic scaffold for dynamic combinatorial library formation. Chemical Communications, 53 (2), 313-316. (doi:10.1039/C6CC07787K).

Record type: Article

Abstract

A novel oligobenzamide-based alpha-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an alpha-helix, and to allow for the facile creation of dynamic libraries.

Text
cc 2016 c6cc07787k.pdf - Version of Record
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 7 November 2016
e-pub ahead of print date: 7 November 2016
Published date: 7 January 2017
Organisations: Chemistry

Identifiers

Local EPrints ID: 403565
URI: https://eprints.soton.ac.uk/id/eprint/403565
ISSN: 1359-7345
PURE UUID: 70b604f6-0170-4783-b2fc-d5cbfa27ac1a
ORCID for Sam Thompson: ORCID iD orcid.org/0000-0001-6267-5693

Catalogue record

Date deposited: 06 Dec 2016 15:44
Last modified: 06 Jun 2018 12:19

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×