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Acid-mediated topological control in a functionalized foldamer

Acid-mediated topological control in a functionalized foldamer
Acid-mediated topological control in a functionalized foldamer
Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helical topologies.
1359-7345
6521-6524
Knipe, Peter C.
a75b6ed7-4d9b-45fc-aacc-49e9e0d0b266
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Knipe, Peter C.
a75b6ed7-4d9b-45fc-aacc-49e9e0d0b266
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd

Knipe, Peter C., Thompson, Sam and Hamilton, Andrew D. (2016) Acid-mediated topological control in a functionalized foldamer. Chemical Communications, 52 (39), 6521-6524. (doi:10.1039/C6CC01496H).

Record type: Article

Abstract

Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helical topologies.

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Accepted/In Press date: 18 March 2016
e-pub ahead of print date: 21 March 2016
Published date: 14 May 2016
Organisations: Chemistry

Identifiers

Local EPrints ID: 403567
URI: http://eprints.soton.ac.uk/id/eprint/403567
ISSN: 1359-7345
PURE UUID: de04793d-9609-46ea-838f-9db6a6207bb6
ORCID for Sam Thompson: ORCID iD orcid.org/0000-0001-6267-5693

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Date deposited: 07 Dec 2016 09:24
Last modified: 17 Dec 2019 01:32

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Contributors

Author: Peter C. Knipe
Author: Sam Thompson ORCID iD
Author: Andrew D. Hamilton

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