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Hybrid diphenylalkyne-dipeptide oligomers induce multistrand B-sheet formation

Hybrid diphenylalkyne-dipeptide oligomers induce multistrand B-sheet formation
Hybrid diphenylalkyne-dipeptide oligomers induce multistrand B-sheet formation
Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand ?-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein–protein interactions.
0947-6539
13518-13521
Ross, Jonathan E.
90459779-9860-40a3-9ce7-4efb14ed15ec
Knipe, Peter C.
a75b6ed7-4d9b-45fc-aacc-49e9e0d0b266
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Ross, Jonathan E.
90459779-9860-40a3-9ce7-4efb14ed15ec
Knipe, Peter C.
a75b6ed7-4d9b-45fc-aacc-49e9e0d0b266
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd

Ross, Jonathan E., Knipe, Peter C., Thompson, Sam and Hamilton, Andrew D. (2015) Hybrid diphenylalkyne-dipeptide oligomers induce multistrand B-sheet formation. Chemistry - A European Journal, 21 (39), 13518-13521. (doi:10.1002/chem.201502690).

Record type: Article

Abstract

Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand ?-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein–protein interactions.

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e-pub ahead of print date: 11 August 2015
Published date: 21 September 2015
Organisations: Chemistry

Identifiers

Local EPrints ID: 403572
URI: http://eprints.soton.ac.uk/id/eprint/403572
ISSN: 0947-6539
PURE UUID: 5df22c60-3154-4936-a44e-7762b7d92d17
ORCID for Sam Thompson: ORCID iD orcid.org/0000-0001-6267-5693

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Date deposited: 07 Dec 2016 09:41
Last modified: 29 Oct 2019 01:33

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Contributors

Author: Jonathan E. Ross
Author: Peter C. Knipe
Author: Sam Thompson ORCID iD
Author: Andrew D. Hamilton

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