Diphenylacetylene-linked peptide strands induce bidirectional B-sheet formation
Diphenylacetylene-linked peptide strands induce bidirectional B-sheet formation
In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein–protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display ?-sheet structures in two directions. Extensive X-ray crystallographic and NMR solution phase studies are consistent with these proteomimetics adopting sheet structures, displaying both hydrophobic and hydrophilic amino acid side chains.
3650-3653
Lingard, Hannah
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Han, Jeongmin T.
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Thompson, Amber L.
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Leung, Ivanhoe K.H.
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Scott, Richard T.W.
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Thompson, Sam
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Hamilton, Andrew D.
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1 April 2014
Lingard, Hannah
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Han, Jeongmin T.
b4e1a512-6d84-40ae-abe6-dba7599b5bbb
Thompson, Amber L.
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Leung, Ivanhoe K.H.
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Scott, Richard T.W.
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Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
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Lingard, Hannah, Han, Jeongmin T., Thompson, Amber L., Leung, Ivanhoe K.H., Scott, Richard T.W., Thompson, Sam and Hamilton, Andrew D.
(2014)
Diphenylacetylene-linked peptide strands induce bidirectional B-sheet formation.
Angewandte Chemie International Edition, 53 (14), .
(doi:10.1002/anie.201309353).
Abstract
In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein–protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display ?-sheet structures in two directions. Extensive X-ray crystallographic and NMR solution phase studies are consistent with these proteomimetics adopting sheet structures, displaying both hydrophobic and hydrophilic amino acid side chains.
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e-pub ahead of print date: 19 February 2014
Published date: 1 April 2014
Organisations:
Chemistry
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Local EPrints ID: 403581
URI: http://eprints.soton.ac.uk/id/eprint/403581
ISSN: 1433-7851
PURE UUID: 67041b04-c2fe-4c0d-b9bb-ba2b26d3db07
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Date deposited: 07 Dec 2016 10:09
Last modified: 15 Mar 2024 03:54
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Contributors
Author:
Hannah Lingard
Author:
Jeongmin T. Han
Author:
Amber L. Thompson
Author:
Ivanhoe K.H. Leung
Author:
Richard T.W. Scott
Author:
Andrew D. Hamilton
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