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Diphenylacetylene-linked peptide strands induce bidirectional B-sheet formation

Diphenylacetylene-linked peptide strands induce bidirectional B-sheet formation
Diphenylacetylene-linked peptide strands induce bidirectional B-sheet formation
In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein–protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display ?-sheet structures in two directions. Extensive X-ray crystallographic and NMR solution phase studies are consistent with these proteomimetics adopting sheet structures, displaying both hydrophobic and hydrophilic amino acid side chains.
1433-7851
3650-3653
Lingard, Hannah
cbd418c5-5067-4649-aec0-df2520e2146e
Han, Jeongmin T.
b4e1a512-6d84-40ae-abe6-dba7599b5bbb
Thompson, Amber L.
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Leung, Ivanhoe K.H.
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Scott, Richard T.W.
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Thompson, Sam
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Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Lingard, Hannah
cbd418c5-5067-4649-aec0-df2520e2146e
Han, Jeongmin T.
b4e1a512-6d84-40ae-abe6-dba7599b5bbb
Thompson, Amber L.
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Leung, Ivanhoe K.H.
0f4fc3a1-9255-4c7e-aae6-26f74ab2af18
Scott, Richard T.W.
b7c85907-eec6-46da-b268-b21c6f5ecb09
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd

Lingard, Hannah, Han, Jeongmin T., Thompson, Amber L., Leung, Ivanhoe K.H., Scott, Richard T.W., Thompson, Sam and Hamilton, Andrew D. (2014) Diphenylacetylene-linked peptide strands induce bidirectional B-sheet formation. Angewandte Chemie International Edition, 53 (14), 3650-3653. (doi:10.1002/anie.201309353).

Record type: Article

Abstract

In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein–protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display ?-sheet structures in two directions. Extensive X-ray crystallographic and NMR solution phase studies are consistent with these proteomimetics adopting sheet structures, displaying both hydrophobic and hydrophilic amino acid side chains.

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e-pub ahead of print date: 19 February 2014
Published date: 1 April 2014
Organisations: Chemistry

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Local EPrints ID: 403581
URI: http://eprints.soton.ac.uk/id/eprint/403581
ISSN: 1433-7851
PURE UUID: 67041b04-c2fe-4c0d-b9bb-ba2b26d3db07
ORCID for Sam Thompson: ORCID iD orcid.org/0000-0001-6267-5693

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Date deposited: 07 Dec 2016 10:09
Last modified: 29 Oct 2019 01:33

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Contributors

Author: Hannah Lingard
Author: Jeongmin T. Han
Author: Amber L. Thompson
Author: Ivanhoe K.H. Leung
Author: Richard T.W. Scott
Author: Sam Thompson ORCID iD
Author: Andrew D. Hamilton

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