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Super-secondary structure peptidomimetics: design and synthesis of an a–a hairpin analogue

Super-secondary structure peptidomimetics: design and synthesis of an a–a hairpin analogue
Super-secondary structure peptidomimetics: design and synthesis of an a–a hairpin analogue
The ?–? helix motif presents key recognition domains in protein–protein and protein–oligonucleotide binding, and is one of the most common super-secondary structures. Herein, we describe the design, synthesis and structural characterisation of an ?–? hairpin analogue based on a tetra-coordinated Pd(II) bis-(iminoisoquinoline) complex as a template for the display of two ?-helix mimics. This approach is exemplified by the attachment of two biphenyl peptidomimetics to reproduce the side chains of the i and i+4 residues of two helices.
1061-0278
586-590
Nevola, Laura
1fa6946c-9170-4c57-a3e7-6f126478a9da
Rodriguez, Johanna M.
461236a5-6434-45d4-b1b1-1d33952dffc2
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Nevola, Laura
1fa6946c-9170-4c57-a3e7-6f126478a9da
Rodriguez, Johanna M.
461236a5-6434-45d4-b1b1-1d33952dffc2
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd

Nevola, Laura, Rodriguez, Johanna M., Thompson, Sam and Hamilton, Andrew D. (2013) Super-secondary structure peptidomimetics: design and synthesis of an a–a hairpin analogue. [in special issue: honouring Professor Rocco Ungaro] Supramolecular Chemistry, 25 (9-11), 586-590. (doi:10.1080/10610278.2013.817581).

Record type: Article

Abstract

The ?–? helix motif presents key recognition domains in protein–protein and protein–oligonucleotide binding, and is one of the most common super-secondary structures. Herein, we describe the design, synthesis and structural characterisation of an ?–? hairpin analogue based on a tetra-coordinated Pd(II) bis-(iminoisoquinoline) complex as a template for the display of two ?-helix mimics. This approach is exemplified by the attachment of two biphenyl peptidomimetics to reproduce the side chains of the i and i+4 residues of two helices.

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Accepted/In Press date: 11 June 2013
e-pub ahead of print date: 21 August 2013
Organisations: Chemistry

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Local EPrints ID: 403586
URI: http://eprints.soton.ac.uk/id/eprint/403586
ISSN: 1061-0278
PURE UUID: debc8744-fac9-43d5-9ce1-27cce6d527ed
ORCID for Sam Thompson: ORCID iD orcid.org/0000-0001-6267-5693

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Date deposited: 07 Dec 2016 10:22
Last modified: 07 Oct 2020 02:09

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Contributors

Author: Laura Nevola
Author: Johanna M. Rodriguez
Author: Sam Thompson ORCID iD
Author: Andrew D. Hamilton

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