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Design and synthesis of oligoamide-based double a-helix mimetics

Design and synthesis of oligoamide-based double a-helix mimetics
Design and synthesis of oligoamide-based double a-helix mimetics
An extensive series of bis-oligobenzamides and bis-oligopyridylamides have been efficiently prepared and studied by X-ray analysis and computational methods. A modular synthesis led to double ?-helix mimics bearing between two and ten branched side-chains. The inter-helix angle and distance can be tuned by varying the length and rigidity of the spacer, thereby reproducing the recognition domains of a range of super-secondary structures.
1434-193X
3433-3445
Kulikov, Oleg V.
bf20410c-70eb-4abb-926e-fce32c7db6aa
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Xu, Hai
9ce740d6-ca75-41d8-9d5c-e9edaadae5e0
Incarvito, Christopher D.
35ef4c2f-9684-4982-9402-0d0b978ab56c
Scott, Richard T.W.
b7c85907-eec6-46da-b268-b21c6f5ecb09
Saraogi, Ishu
42a07959-549a-443c-b126-02e468963352
Nevola, Laura
1fa6946c-9170-4c57-a3e7-6f126478a9da
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Kulikov, Oleg V.
bf20410c-70eb-4abb-926e-fce32c7db6aa
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Xu, Hai
9ce740d6-ca75-41d8-9d5c-e9edaadae5e0
Incarvito, Christopher D.
35ef4c2f-9684-4982-9402-0d0b978ab56c
Scott, Richard T.W.
b7c85907-eec6-46da-b268-b21c6f5ecb09
Saraogi, Ishu
42a07959-549a-443c-b126-02e468963352
Nevola, Laura
1fa6946c-9170-4c57-a3e7-6f126478a9da
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd

Kulikov, Oleg V., Thompson, Sam, Xu, Hai, Incarvito, Christopher D., Scott, Richard T.W., Saraogi, Ishu, Nevola, Laura and Hamilton, Andrew D. (2013) Design and synthesis of oligoamide-based double a-helix mimetics. European Journal of Organic Chemistry, 2013 (17), 3433-3445. (doi:10.1002/ejoc.201300363).

Record type: Article

Abstract

An extensive series of bis-oligobenzamides and bis-oligopyridylamides have been efficiently prepared and studied by X-ray analysis and computational methods. A modular synthesis led to double ?-helix mimics bearing between two and ten branched side-chains. The inter-helix angle and distance can be tuned by varying the length and rigidity of the spacer, thereby reproducing the recognition domains of a range of super-secondary structures.

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e-pub ahead of print date: 23 May 2013
Published date: June 2013
Organisations: Chemistry

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Local EPrints ID: 403605
URI: http://eprints.soton.ac.uk/id/eprint/403605
ISSN: 1434-193X
PURE UUID: af35db12-b9fd-4efb-b05a-cac47b66d4df
ORCID for Sam Thompson: ORCID iD orcid.org/0000-0001-6267-5693

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Date deposited: 07 Dec 2016 11:35
Last modified: 10 Dec 2019 01:31

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Contributors

Author: Oleg V. Kulikov
Author: Sam Thompson ORCID iD
Author: Hai Xu
Author: Christopher D. Incarvito
Author: Richard T.W. Scott
Author: Ishu Saraogi
Author: Laura Nevola
Author: Andrew D. Hamilton

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