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Design and synthesis of oligoamide-based double a-helix mimetics (Eur. J. Org. Chem. 17/2013)

Design and synthesis of oligoamide-based double a-helix mimetics (Eur. J. Org. Chem. 17/2013)
Design and synthesis of oligoamide-based double a-helix mimetics (Eur. J. Org. Chem. 17/2013)
The cover picture shows the binding of transcription factors to nucleic acids. Top left: multicomponent protein; bottom right: leucine zipper; centre: bis-oligobenzamide peptidomimetic; background: DNA chains. The xanthene-linked bis-oligobenzamide shown in the centre is an example of a super-secondary structural protein mimic. This work details the synthesis of oligobenzamide and oligopyridylamide strands connected through various spacers, allowing tuning of the inter-helix angle and thus the potential nucleic acid or protein binding properties. Details are discussed in the article by A. D. Hamilton et al. on page 3427 ff.
1434-193X
Kulikov, Oleg V.
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Thompson, Sam
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Xu, Hai
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Incarvito, Christopher D.
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Scott, Richard T.W.
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Saraogi, Ishu
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Nevola, Laura
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Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Kulikov, Oleg V.
bf20410c-70eb-4abb-926e-fce32c7db6aa
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Xu, Hai
9ce740d6-ca75-41d8-9d5c-e9edaadae5e0
Incarvito, Christopher D.
35ef4c2f-9684-4982-9402-0d0b978ab56c
Scott, Richard T.W.
b7c85907-eec6-46da-b268-b21c6f5ecb09
Saraogi, Ishu
42a07959-549a-443c-b126-02e468963352
Nevola, Laura
1fa6946c-9170-4c57-a3e7-6f126478a9da
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd

Kulikov, Oleg V., Thompson, Sam, Xu, Hai, Incarvito, Christopher D., Scott, Richard T.W., Saraogi, Ishu, Nevola, Laura and Hamilton, Andrew D. (2013) Design and synthesis of oligoamide-based double a-helix mimetics (Eur. J. Org. Chem. 17/2013). [in special issue: Foldamers] European Journal of Organic Chemistry, 2013 (17). (doi:10.1002/ejoc.201390045).

Record type: Article

Abstract

The cover picture shows the binding of transcription factors to nucleic acids. Top left: multicomponent protein; bottom right: leucine zipper; centre: bis-oligobenzamide peptidomimetic; background: DNA chains. The xanthene-linked bis-oligobenzamide shown in the centre is an example of a super-secondary structural protein mimic. This work details the synthesis of oligobenzamide and oligopyridylamide strands connected through various spacers, allowing tuning of the inter-helix angle and thus the potential nucleic acid or protein binding properties. Details are discussed in the article by A. D. Hamilton et al. on page 3427 ff.

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Published date: June 2013
Organisations: Chemistry

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Local EPrints ID: 403607
URI: http://eprints.soton.ac.uk/id/eprint/403607
ISSN: 1434-193X
PURE UUID: e85071a2-7fa6-46be-9085-976c28dd90ff
ORCID for Sam Thompson: ORCID iD orcid.org/0000-0001-6267-5693

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Date deposited: 07 Dec 2016 13:24
Last modified: 22 Jul 2020 00:36

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Contributors

Author: Oleg V. Kulikov
Author: Sam Thompson ORCID iD
Author: Hai Xu
Author: Christopher D. Incarvito
Author: Richard T.W. Scott
Author: Ishu Saraogi
Author: Laura Nevola
Author: Andrew D. Hamilton

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