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Aryl-linked imidazolidin-2-ones as non-peptidic beta-strand mimetics

Aryl-linked imidazolidin-2-ones as non-peptidic beta-strand mimetics
Aryl-linked imidazolidin-2-ones as non-peptidic beta-strand mimetics
We describe the design and synthesis of a non-peptidic beta-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.
1359-7345
9834-9836
Sutherell, Charlotte L.
86a70583-fccb-49e8-8294-435cd7722a89
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Scott, Richard T.W.
b7c85907-eec6-46da-b268-b21c6f5ecb09
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Sutherell, Charlotte L.
86a70583-fccb-49e8-8294-435cd7722a89
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Scott, Richard T.W.
b7c85907-eec6-46da-b268-b21c6f5ecb09
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd

Sutherell, Charlotte L., Thompson, Sam, Scott, Richard T.W. and Hamilton, Andrew D. (2012) Aryl-linked imidazolidin-2-ones as non-peptidic beta-strand mimetics. Chemical Communications, 48 (79), 9834-9836. (doi:10.1039/C2CC34791A).

Record type: Article

Abstract

We describe the design and synthesis of a non-peptidic beta-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.

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Published date: 26 July 2012
Organisations: Chemistry

Identifiers

Local EPrints ID: 403609
URI: http://eprints.soton.ac.uk/id/eprint/403609
ISSN: 1359-7345
PURE UUID: 228be823-9fb6-4d3a-be18-6e7d5a5c4a00
ORCID for Sam Thompson: ORCID iD orcid.org/0000-0001-6267-5693

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Date deposited: 06 Dec 2016 16:43
Last modified: 20 Jul 2019 00:32

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