Amphiphilic a-helix mimetics based on a benzoylurea scaffold
Amphiphilic a-helix mimetics based on a benzoylurea scaffold
The design and synthesis of amphiphilic benzoylurea ?-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an ?-helix.
5780-5782
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Thompson, Sam and Hamilton, Andrew D.
(2012)
Amphiphilic a-helix mimetics based on a benzoylurea scaffold.
[in special issue: Organic & Biomolecular Chemistry 10th Anniversary]
Organic & Biomolecular Chemistry, 10 (30), .
(doi:10.1039/C2OB25273B).
Abstract
The design and synthesis of amphiphilic benzoylurea ?-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an ?-helix.
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Accepted/In Press date: 19 March 2012
e-pub ahead of print date: 25 April 2012
Organisations:
Chemistry
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Local EPrints ID: 403610
URI: http://eprints.soton.ac.uk/id/eprint/403610
ISSN: 1477-0520
PURE UUID: 6d946d4d-b5a7-45ad-ac15-7ca177bb40ea
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Date deposited: 07 Dec 2016 13:31
Last modified: 15 Mar 2024 03:54
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Author:
Andrew D. Hamilton
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