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Amphiphilic a-helix mimetics based on a benzoylurea scaffold

Amphiphilic a-helix mimetics based on a benzoylurea scaffold
Amphiphilic a-helix mimetics based on a benzoylurea scaffold
The design and synthesis of amphiphilic benzoylurea ?-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an ?-helix.
1477-0520
5780-5782
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd
Thompson, Sam
99b7e34e-fe24-401c-b7b0-64e56cbbbcb1
Hamilton, Andrew D.
048a6c75-91bf-4555-ab12-ce885eee65dd

Thompson, Sam and Hamilton, Andrew D. (2012) Amphiphilic a-helix mimetics based on a benzoylurea scaffold. [in special issue: Organic & Biomolecular Chemistry 10th Anniversary] Organic & Biomolecular Chemistry, 10 (30), 5780-5782. (doi:10.1039/C2OB25273B).

Record type: Article

Abstract

The design and synthesis of amphiphilic benzoylurea ?-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an ?-helix.

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Accepted/In Press date: 19 March 2012
e-pub ahead of print date: 25 April 2012
Organisations: Chemistry

Identifiers

Local EPrints ID: 403610
URI: http://eprints.soton.ac.uk/id/eprint/403610
ISSN: 1477-0520
PURE UUID: 6d946d4d-b5a7-45ad-ac15-7ca177bb40ea
ORCID for Sam Thompson: ORCID iD orcid.org/0000-0001-6267-5693

Catalogue record

Date deposited: 07 Dec 2016 13:31
Last modified: 03 Dec 2019 01:32

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