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An exploratory study of the physiological correlates of neurodevelopmental delay in infants with sickle cell anaemia

Prengler, M., Kirkham, F.J, Hogan, A.M, Telfer, P., Lane, R., Vargha-Khadem, F. and De Haan, M. (2005) An exploratory study of the physiological correlates of neurodevelopmental delay in infants with sickle cell anaemia British Journal of Haematology, 132, (1), pp. 99-107. (doi:10.1111/j.1365-2141.2005.05828.x).

Record type: Article


This study aimed to investigate whether infants with sickle cell anaemia (SCA) are at risk of neurodevelopmental delay, and whether any delay is associated with SCA pathology. Twenty-eight infants (14 SCA; 14 age- and ethnic-similar controls) were assessed longitudinally with the Bayley Infant Neurodevelopmental Screener (BINS) at 3, 9 and 12 months. Transcranial Doppler (TCD) and pulse oximetry (SpO2) measures were recorded longitudinally in SCA infants, and a subgroup of controls. Haemoglobin values were obtained from SCA infants. At each age, SCA infants obtained BINS scores indicative of greater risk of neurodevelopmental delay compared with controls. The number of moderate–high BINS risk scores increased significantly between 3 and 9 months. At 9 months BINS raw scores correlated negatively with TCD velocity and positively with haemoglobin. This exploratory study suggests that SCA infants may be at greater risk of neurodevelopmental delay than previously considered, and may provide the impetus for further research into the very early precursors of cognitive impairment.

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Published date: 2005


Local EPrints ID: 40367
ISSN: 0007-1048
PURE UUID: 8e8ee00e-fc77-45fd-8be5-8c85f8f49f74

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Date deposited: 03 Jul 2006
Last modified: 17 Jul 2017 15:34

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Author: M. Prengler
Author: F.J Kirkham
Author: A.M Hogan
Author: P. Telfer
Author: R. Lane
Author: F. Vargha-Khadem
Author: M. De Haan

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