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Modified profile of matrix metalloproteinase-2 and -9 production by human Fallopian tube epithelial cells following infection in vitro with Neisseria gonorrhoeae

Modified profile of matrix metalloproteinase-2 and -9 production by human Fallopian tube epithelial cells following infection in vitro with Neisseria gonorrhoeae
Modified profile of matrix metalloproteinase-2 and -9 production by human Fallopian tube epithelial cells following infection in vitro with Neisseria gonorrhoeae
Epithelial shedding and scarring of Fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and likely involves an imbalance of host extracellular matrix components (ECM) and their regulators such as matrix metalloproteinases (MMPs). In this brief report, primary human Fallopian tube epithelial cells were infected with N. gonorrhoeae and MMP patterns examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.
0022-1899
452-455
Rodas, Paula
f74e9acd-7b1f-4527-a382-de29792c1d8f
Perez, Doris
8a6656c6-33d2-4903-b734-f3180b3759c0
Jauffret, Claudia
60fdf9f5-685b-4795-af71-f9509b2b5145
Gonzalez, Yaquelin
756e441d-cac1-460f-bf80-e874c26b4f61
Carreno, Carolina
393f04a9-154b-4d94-b06a-4cdf8af45f10
Tapia, Cecilia
0460ce8b-c9b2-4b59-bfb3-2613c29b51b6
Osorio, Eduardo
ddc83c3b-6e0c-40f0-9af7-0723d844d263
Velasquez, Luis
c9daa27f-8aaa-41fc-9f2d-ffeadfaa2008
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Rodas, Paula
f74e9acd-7b1f-4527-a382-de29792c1d8f
Perez, Doris
8a6656c6-33d2-4903-b734-f3180b3759c0
Jauffret, Claudia
60fdf9f5-685b-4795-af71-f9509b2b5145
Gonzalez, Yaquelin
756e441d-cac1-460f-bf80-e874c26b4f61
Carreno, Carolina
393f04a9-154b-4d94-b06a-4cdf8af45f10
Tapia, Cecilia
0460ce8b-c9b2-4b59-bfb3-2613c29b51b6
Osorio, Eduardo
ddc83c3b-6e0c-40f0-9af7-0723d844d263
Velasquez, Luis
c9daa27f-8aaa-41fc-9f2d-ffeadfaa2008
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078

Rodas, Paula, Perez, Doris, Jauffret, Claudia, Gonzalez, Yaquelin, Carreno, Carolina, Tapia, Cecilia, Osorio, Eduardo, Velasquez, Luis and Christodoulides, Myron (2017) Modified profile of matrix metalloproteinase-2 and -9 production by human Fallopian tube epithelial cells following infection in vitro with Neisseria gonorrhoeae. The Journal of Infectious Diseases, 215 (3), 452-455. (doi:10.1093/infdis/jiw568). (PMID:27932616)

Record type: Article

Abstract

Epithelial shedding and scarring of Fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and likely involves an imbalance of host extracellular matrix components (ECM) and their regulators such as matrix metalloproteinases (MMPs). In this brief report, primary human Fallopian tube epithelial cells were infected with N. gonorrhoeae and MMP patterns examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.

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J Infect Dis.-2016-Rodas-infdis_jiw568.pdf - Accepted Manuscript
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Accepted/In Press date: 20 November 2016
e-pub ahead of print date: 8 December 2016
Published date: 1 February 2017
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 403964
URI: http://eprints.soton.ac.uk/id/eprint/403964
ISSN: 0022-1899
PURE UUID: 41e35519-5040-488e-8463-9281e1b92baa
ORCID for Myron Christodoulides: ORCID iD orcid.org/0000-0002-9663-4731

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Date deposited: 19 Dec 2016 09:47
Last modified: 18 Feb 2021 16:37

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Contributors

Author: Paula Rodas
Author: Doris Perez
Author: Claudia Jauffret
Author: Yaquelin Gonzalez
Author: Carolina Carreno
Author: Cecilia Tapia
Author: Eduardo Osorio
Author: Luis Velasquez

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