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Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted
217.e1-217.e4
Wang, Lisa
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Wang, Lisa
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Krüger, Rejko
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Farrer, Matthew J.
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Ross, Owen A.
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Sharma, Manu
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Wang, Lisa, Heckman, Michael G., Aasly, Jan O., Annesi, Grazia, Bozi, Maria, Chung, Sun Ju, Clarke, Carl, Crosiers, David, Eckstein, Gertrud, Garraux, Gaetan, Hadjigeorgiou, Georgios M., Hattori, Nobu, Jeon, Beom, Kim, Yun J., Kubo, Masato, Lesage, Suzanne, Lin, Juei Jueng, Lynch, Timothy, Lichtner, Peter, Mellick, George D., Mok, Vincent, Morrison, Karin, Quattrone, Aldo, Satake, Wataru, Silburn, Peter A., Stefanis, Leonidas, Stockton, Joanne D., Tan, Eng King, Toda, Tatsushi, Brice, Alexis, Van Broeckhoven, Christine, Uitti, Ryan J., Wirdefeldt, Karin, Wszolek, Zbigniew, Xiromerisiou, Georgia, Maraganore, Demetrius M., Gasser, Thomas, Krüger, Rejko, Farrer, Matthew J., Ross, Owen A. and Sharma, Manu (2016) Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of Aging, 49, 217.e1-217.e4. (doi:10.1016/j.neurobiolaging.2016.09.022).

Record type: Article

Abstract

A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted

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Accepted/In Press date: 28 September 2016
Published date: 6 October 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 403966
URI: http://eprints.soton.ac.uk/id/eprint/403966
PURE UUID: 659dccdd-047d-439f-8118-7d5975333d9f
ORCID for Karin Morrison: ORCID iD orcid.org/0000-0003-0216-5717

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Date deposited: 16 Dec 2016 09:08
Last modified: 07 Oct 2020 04:01

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Contributors

Author: Lisa Wang
Author: Michael G. Heckman
Author: Jan O. Aasly
Author: Grazia Annesi
Author: Maria Bozi
Author: Sun Ju Chung
Author: Carl Clarke
Author: David Crosiers
Author: Gertrud Eckstein
Author: Gaetan Garraux
Author: Georgios M. Hadjigeorgiou
Author: Nobu Hattori
Author: Beom Jeon
Author: Yun J. Kim
Author: Masato Kubo
Author: Suzanne Lesage
Author: Juei Jueng Lin
Author: Timothy Lynch
Author: Peter Lichtner
Author: George D. Mellick
Author: Vincent Mok
Author: Karin Morrison ORCID iD
Author: Aldo Quattrone
Author: Wataru Satake
Author: Peter A. Silburn
Author: Leonidas Stefanis
Author: Joanne D. Stockton
Author: Eng King Tan
Author: Tatsushi Toda
Author: Alexis Brice
Author: Christine Van Broeckhoven
Author: Ryan J. Uitti
Author: Karin Wirdefeldt
Author: Zbigniew Wszolek
Author: Georgia Xiromerisiou
Author: Demetrius M. Maraganore
Author: Thomas Gasser
Author: Rejko Krüger
Author: Matthew J. Farrer
Author: Owen A. Ross
Author: Manu Sharma

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