Askew, Katharine, Li, Kaizhen, Olmos-Alonso, Adrian, Garcia-Moreno, Fernando, Liang, Yajie, Richardson, Philippa, Tipton, Thomas, Chapman, Mark, Riecken, Kristoffer, Beccari, Sol, Sierra, Amanda, Molnar, Zoltan, Cragg, Mark S., Garaschuk, Olga, Perry, V. Hugh and Gomez-Nicola, Diego (2017) Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain. Cell Reports, 18 (2), 391-405. (doi:10.1016/j.celrep.2016.12.041).
Abstract
Summary
Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.
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- Faculties (pre 2018 reorg) > Faculty of Natural and Environmental Sciences (pre 2018 reorg) > Biological Sciences (pre 2018 reorg)
Current Faculties > Faculty of Environmental and Life Sciences > School of Biological Sciences > Biological Sciences (pre 2018 reorg)
School of Biological Sciences > Biological Sciences (pre 2018 reorg) - Faculties (pre 2018 reorg) > Faculty of Engineering and the Environment (pre 2018 reorg) > Southampton Marine & Maritime Institute (pre 2018 reorg)
- Faculties (pre 2018 reorg) > Faculty of Natural and Environmental Sciences (pre 2018 reorg) > Biological Sciences (pre 2018 reorg) > Biological Sciences Technical (pre 2018 reorg)
Current Faculties > Faculty of Environmental and Life Sciences > School of Biological Sciences > Biological Sciences (pre 2018 reorg) > Biological Sciences Technical (pre 2018 reorg)
School of Biological Sciences > Biological Sciences (pre 2018 reorg) > Biological Sciences Technical (pre 2018 reorg) - Faculties (pre 2018 reorg) > Faculty of Natural and Environmental Sciences (pre 2018 reorg) > Biological Sciences (pre 2018 reorg) > Biomedicine (pre 2018 reorg)
Current Faculties > Faculty of Environmental and Life Sciences > School of Biological Sciences > Biological Sciences (pre 2018 reorg) > Biomedicine (pre 2018 reorg)
School of Biological Sciences > Biological Sciences (pre 2018 reorg) > Biomedicine (pre 2018 reorg) - Faculties (pre 2018 reorg) > Faculty of Natural and Environmental Sciences (pre 2018 reorg) > Biological Sciences (pre 2018 reorg) > Environmental (pre 2018 reorg)
Current Faculties > Faculty of Environmental and Life Sciences > School of Biological Sciences > Biological Sciences (pre 2018 reorg) > Environmental (pre 2018 reorg)
School of Biological Sciences > Biological Sciences (pre 2018 reorg) > Environmental (pre 2018 reorg) - Faculties (pre 2018 reorg) > Faculty of Medicine (pre 2018 reorg) > Cancer Sciences (pre 2018 reorg)
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