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A neural substrate for nonpainful phantom limb phenomena

A neural substrate for nonpainful phantom limb phenomena
A neural substrate for nonpainful phantom limb phenomena
Activity in the cerebral cortex associated with non-painful phantom limb sensation was studied in 14 upper extremity amputees. In four subjects, repetitive tactile stimulation of the digits or the lower corner of the mouth elicited non-painful phantom sensation in the amputated limb, in the remaining 10 patients no sensation could be evoked. Neuroelectric source imaging revealed significantly elevated activity in SI and posterior parietal cortex, and significantly decreased activity in ipsilateral SII cortex when referred sensations were present. However, nonpainful referred phantom sensations were not associated with a shift of the cortical representation of the mouth into the hand region, as previously suggested. Non-painful phantom limb experiences seem to have widely distributed neural networks in multiple cortical regions.
1407-1411
Flor, Herta
4bd4c786-cfc6-4639-8dab-893f73dc4c88
Mühlnickel, Werner
85bacc4e-c6c0-4de7-a89c-6ade75ae7984
Karl, Anke
7f091050-641c-4658-a247-785cfd194c3d
Denke, Claudia
0db4c7a8-092e-48e8-a4cb-fe3a1bf2fc0a
Grüsser, Sabine
c711ffa6-03a6-400e-bd6b-485d3c2fd53f
Taub, Edward
a074e846-0c23-41f4-a910-ea01e8933944
Flor, Herta
4bd4c786-cfc6-4639-8dab-893f73dc4c88
Mühlnickel, Werner
85bacc4e-c6c0-4de7-a89c-6ade75ae7984
Karl, Anke
7f091050-641c-4658-a247-785cfd194c3d
Denke, Claudia
0db4c7a8-092e-48e8-a4cb-fe3a1bf2fc0a
Grüsser, Sabine
c711ffa6-03a6-400e-bd6b-485d3c2fd53f
Taub, Edward
a074e846-0c23-41f4-a910-ea01e8933944

Flor, Herta, Mühlnickel, Werner, Karl, Anke, Denke, Claudia, Grüsser, Sabine and Taub, Edward (2000) A neural substrate for nonpainful phantom limb phenomena. Neuroreport, 11 (7), 1407-1411.

Record type: Article

Abstract

Activity in the cerebral cortex associated with non-painful phantom limb sensation was studied in 14 upper extremity amputees. In four subjects, repetitive tactile stimulation of the digits or the lower corner of the mouth elicited non-painful phantom sensation in the amputated limb, in the remaining 10 patients no sensation could be evoked. Neuroelectric source imaging revealed significantly elevated activity in SI and posterior parietal cortex, and significantly decreased activity in ipsilateral SII cortex when referred sensations were present. However, nonpainful referred phantom sensations were not associated with a shift of the cortical representation of the mouth into the hand region, as previously suggested. Non-painful phantom limb experiences seem to have widely distributed neural networks in multiple cortical regions.

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Published date: 2000

Identifiers

Local EPrints ID: 40401
URI: https://eprints.soton.ac.uk/id/eprint/40401
PURE UUID: 2824866f-641b-43f3-bdca-78378a4b54bc

Catalogue record

Date deposited: 19 Jul 2006
Last modified: 17 Jul 2017 15:34

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