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Modelling nutrient transfer based on 3D imaging of the human placental microstructure

Modelling nutrient transfer based on 3D imaging of the human placental microstructure
Modelling nutrient transfer based on 3D imaging of the human placental microstructure
Impaired transfer of nutrients from mother to fetus can affect pregnancy outcomes. The placenta has a complex microstructure, including the maternal intervillous space and fetal capillaries. Previous computational models of placental transfer either assumed a simplified idealized local geometry or were based on 2D imaging. In this study, we present a novel 3D computational model to assess the placental transfer of nutrients at the microscale in interaction with the maternal flow environment. A stack of confocal microscopy images of the placental terminal villi was collected and reconstructed. The 3D simulation framework was tested for the transport of oxygen. Preliminary results identified local stagnant zones, as well as areas of high nutrient transfer into the fetal capillaries in the most exposed branches of the villi as a result of better perfusion, combined with a smaller thickness of the tissue barrier. Overall, the current model may serve as a tool for assessing pregnancy conditions affected by inefficient nutrient transfer due to altered microscale placental morphology.
Perazzolo, Simone
bc5e3f83-6eb6-4ed6-9173-860a2d03817d
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Sengers, Bram
d6b771b1-4ede-48c5-9644-fa86503941aa
Perazzolo, Simone
bc5e3f83-6eb6-4ed6-9173-860a2d03817d
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Sengers, Bram
d6b771b1-4ede-48c5-9644-fa86503941aa

Perazzolo, Simone, Lewis, Rohan and Sengers, Bram (2016) Modelling nutrient transfer based on 3D imaging of the human placental microstructure. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2016 (EMBC), United States. 4 pp . (doi:10.1109/EMBC.2016.7592084).

Record type: Conference or Workshop Item (Paper)

Abstract

Impaired transfer of nutrients from mother to fetus can affect pregnancy outcomes. The placenta has a complex microstructure, including the maternal intervillous space and fetal capillaries. Previous computational models of placental transfer either assumed a simplified idealized local geometry or were based on 2D imaging. In this study, we present a novel 3D computational model to assess the placental transfer of nutrients at the microscale in interaction with the maternal flow environment. A stack of confocal microscopy images of the placental terminal villi was collected and reconstructed. The 3D simulation framework was tested for the transport of oxygen. Preliminary results identified local stagnant zones, as well as areas of high nutrient transfer into the fetal capillaries in the most exposed branches of the villi as a result of better perfusion, combined with a smaller thickness of the tissue barrier. Overall, the current model may serve as a tool for assessing pregnancy conditions affected by inefficient nutrient transfer due to altered microscale placental morphology.

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More information

e-pub ahead of print date: August 2016
Published date: 18 October 2016
Venue - Dates: 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2016 (EMBC), United States, 2016-08-01
Organisations: Engineering Science Unit

Identifiers

Local EPrints ID: 404170
URI: http://eprints.soton.ac.uk/id/eprint/404170
PURE UUID: 4a46efac-9007-4661-9f28-65445bee5863
ORCID for Rohan Lewis: ORCID iD orcid.org/0000-0003-4044-9104
ORCID for Bram Sengers: ORCID iD orcid.org/0000-0001-5859-6984

Catalogue record

Date deposited: 03 Jan 2017 11:59
Last modified: 20 Jul 2019 01:05

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