Neurological complications and MRI
Neurological complications and MRI
Cerebrovascular disease (cerebral infarction, intracranial haemorrhage, vasculopathy) are common manifestations of SCD associated with significant morbidity and mortality. These neurological complications and potential corresponding neuropsychological compromise may have devastating consequences for a child with SCD. This chapter aims to review the neurological complications in SCD using magnetic resonance imaging (MRI) as both a qualitative and quantitative tool for detecting abnormality. Advanced MRI pulse sequences, such as high-resolution 3D T1-weighted imaging for brain volumetrics, diffusion tensor imaging for white matter integrity and non-invasive perfusion MRI for cerebral blood flow measurement, can give additional information about the structure and function of brain tissue beyond the scope of conventional clinical imaging. These studies have set to establish quantitative biomarkers that relate to disease severity and neuropsychological sequelae.
127-152
Kawadler, Jamie M.
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Kirkham, Fenella J.
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Kawadler, Jamie M.
7d035760-69ea-4b6c-8a7a-771b73453db8
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Kawadler, Jamie M. and Kirkham, Fenella J.
(2016)
Neurological complications and MRI.
In,
Sickle Cell Disease - Pain and Common Chronic Complicaitions.
Rijeka, HR.
Intech, .
(doi:10.5772/64143).
Record type:
Book Section
Abstract
Cerebrovascular disease (cerebral infarction, intracranial haemorrhage, vasculopathy) are common manifestations of SCD associated with significant morbidity and mortality. These neurological complications and potential corresponding neuropsychological compromise may have devastating consequences for a child with SCD. This chapter aims to review the neurological complications in SCD using magnetic resonance imaging (MRI) as both a qualitative and quantitative tool for detecting abnormality. Advanced MRI pulse sequences, such as high-resolution 3D T1-weighted imaging for brain volumetrics, diffusion tensor imaging for white matter integrity and non-invasive perfusion MRI for cerebral blood flow measurement, can give additional information about the structure and function of brain tissue beyond the scope of conventional clinical imaging. These studies have set to establish quantitative biomarkers that relate to disease severity and neuropsychological sequelae.
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e-pub ahead of print date: 10 November 2016
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 404241
URI: http://eprints.soton.ac.uk/id/eprint/404241
PURE UUID: 9fd94fa9-4f1c-4af8-91c7-faac04a1ad9e
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Date deposited: 04 Jan 2017 16:19
Last modified: 16 Mar 2024 03:22
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Author:
Jamie M. Kawadler
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