The University of Southampton
University of Southampton Institutional Repository

Neurological complications and MRI

Neurological complications and MRI
Neurological complications and MRI
Cerebrovascular disease (cerebral infarction, intracranial haemorrhage, vasculopathy) are common manifestations of SCD associated with significant morbidity and mortality. These neurological complications and potential corresponding neuropsychological compromise may have devastating consequences for a child with SCD. This chapter aims to review the neurological complications in SCD using magnetic resonance imaging (MRI) as both a qualitative and quantitative tool for detecting abnormality. Advanced MRI pulse sequences, such as high-resolution 3D T1-weighted imaging for brain volumetrics, diffusion tensor imaging for white matter integrity and non-invasive perfusion MRI for cerebral blood flow measurement, can give additional information about the structure and function of brain tissue beyond the scope of conventional clinical imaging. These studies have set to establish quantitative biomarkers that relate to disease severity and neuropsychological sequelae.
127-152
IN TECH
Kawadler, Jamie M.
7d035760-69ea-4b6c-8a7a-771b73453db8
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Kawadler, Jamie M.
7d035760-69ea-4b6c-8a7a-771b73453db8
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58

Kawadler, Jamie M. and Kirkham, Fenella J. (2016) Neurological complications and MRI. In, Sickle Cell Disease - Pain and Common Chronic Complicaitions. Rijeka, HR. IN TECH, pp. 127-152. (doi:10.5772/64143).

Record type: Book Section

Abstract

Cerebrovascular disease (cerebral infarction, intracranial haemorrhage, vasculopathy) are common manifestations of SCD associated with significant morbidity and mortality. These neurological complications and potential corresponding neuropsychological compromise may have devastating consequences for a child with SCD. This chapter aims to review the neurological complications in SCD using magnetic resonance imaging (MRI) as both a qualitative and quantitative tool for detecting abnormality. Advanced MRI pulse sequences, such as high-resolution 3D T1-weighted imaging for brain volumetrics, diffusion tensor imaging for white matter integrity and non-invasive perfusion MRI for cerebral blood flow measurement, can give additional information about the structure and function of brain tissue beyond the scope of conventional clinical imaging. These studies have set to establish quantitative biomarkers that relate to disease severity and neuropsychological sequelae.

Text
Neurological complications and MRI_final.docx - Accepted Manuscript
Available under License Other.
Download (178kB)
Text
51430.pdf - Version of Record
Available under License Other.
Download (6MB)

More information

e-pub ahead of print date: 10 November 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 404241
URI: https://eprints.soton.ac.uk/id/eprint/404241
PURE UUID: 9fd94fa9-4f1c-4af8-91c7-faac04a1ad9e
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

Catalogue record

Date deposited: 04 Jan 2017 16:19
Last modified: 13 Jun 2019 00:37

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×