Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons
Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons
Most cortical neurons fire regularly when excited by a constant stimulus. In contrast, irregular-spiking (IS) interneurons are remarkable for the intrinsic variability of their spike timing, which can synchronize amongst IS cells via specific gap junctions. Here, we have studied the biophysical mechanisms of this irregular spiking in mice, and how IS cells fire in the context of synchronous network oscillations. Using patch-clamp recordings, artificial dynamic conductance injection, pharmacological analysis and computational modeling, we show that spike time irregularity is generated by a nonlinear dynamical interaction of voltage-dependent sodium and fast-inactivating potassium channels just below spike threshold, amplifying channel noise. This active irregularity may help IS cells synchronize with each other at gamma range frequencies, while resisting synchronization to lower input frequencies.
Mendonça, Philipe R.F.
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Vargas-Caballero, Mariana
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Erdélyi, Ferenc
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Szabó, Gábor
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Paulsen, Ole
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Robinson, Hugh P.C.
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20 September 2016
Mendonça, Philipe R.F.
e3b5a9be-94f7-40ef-ad2b-cec5296ed20d
Vargas-Caballero, Mariana
de2178ac-77fd-4748-9fe5-109ab8ad93e1
Erdélyi, Ferenc
45e745a8-33c5-4da0-b173-98bc8d3f4193
Szabó, Gábor
1b9e0881-2717-4dd8-9b33-f0fddce33916
Paulsen, Ole
fb305f62-2a16-48b0-921a-2cbc59b85c1f
Robinson, Hugh P.C.
9e490d5e-ab13-42f4-bee8-8dc5312bad83
Mendonça, Philipe R.F., Vargas-Caballero, Mariana, Erdélyi, Ferenc, Szabó, Gábor, Paulsen, Ole and Robinson, Hugh P.C.
(2016)
Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons.
eLife, 5, [e16475].
(doi:10.7554/eLife.16475).
(PMID:27536875)
Abstract
Most cortical neurons fire regularly when excited by a constant stimulus. In contrast, irregular-spiking (IS) interneurons are remarkable for the intrinsic variability of their spike timing, which can synchronize amongst IS cells via specific gap junctions. Here, we have studied the biophysical mechanisms of this irregular spiking in mice, and how IS cells fire in the context of synchronous network oscillations. Using patch-clamp recordings, artificial dynamic conductance injection, pharmacological analysis and computational modeling, we show that spike time irregularity is generated by a nonlinear dynamical interaction of voltage-dependent sodium and fast-inactivating potassium channels just below spike threshold, amplifying channel noise. This active irregularity may help IS cells synchronize with each other at gamma range frequencies, while resisting synchronization to lower input frequencies.
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Accepted/In Press date: 17 August 2016
e-pub ahead of print date: 18 August 2016
Published date: 20 September 2016
Organisations:
Biomedicine
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Local EPrints ID: 404309
URI: http://eprints.soton.ac.uk/id/eprint/404309
PURE UUID: 865cadf5-00cf-4881-99d9-bd04bb15e752
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Date deposited: 05 Jan 2017 14:33
Last modified: 16 Mar 2024 04:11
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Contributors
Author:
Philipe R.F. Mendonça
Author:
Ferenc Erdélyi
Author:
Gábor Szabó
Author:
Ole Paulsen
Author:
Hugh P.C. Robinson
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