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Review of the development of methods for characterization of microspheres for use in embolotherapy: translating Bench to Cathlab

Review of the development of methods for characterization of microspheres for use in embolotherapy: translating Bench to Cathlab
Review of the development of methods for characterization of microspheres for use in embolotherapy: translating Bench to Cathlab
Therapeutic embolotherapy is the deliberate occlusion of a blood vessel within the body, which can be for the prevention of internal bleeding, stemming of flow through an arteriovenous malformation, or occlusion of blood vessels feeding a tumour. This is achieved using a wide selection of embolic devices such as; balloons, coils, gels, glues and particles.

Particulate embolization is often favoured for blocking smaller vessels, particularly within hyper-vascularised tumours, as they are available in calibrated sizes and can be delivered distally via microcatheters for precise occlusion with associated locoregional drug delivery.

Embolic performance has been traditionally evaluated using animal models, but with increasing interest in the 3R’s (Replacement, Reduction, Refinement), manufacturers, regulators and clinicians have shown interest in the development of more sophisticated in vitro methods for evaluation and prediction of in vivo performance. Herein we review the current progress in developing bespoke techniques incorporating; physical handling, fluid dynamics, occlusive behaviour and sustained drug elution kinetics within vascular systems.

Whilst it is necessary to continue to validate the safety of such devices in vivo, great strides have been made in the development of bench tests that better predict the behaviour of these products aligned with the principles of the 3R’s.
2192-2659
Caine, Marcus
b32f8e4b-3a11-47eb-9600-2eea10e87b8a
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Dreher, Matthew R.
dd5e6291-6a16-4ad2-ae5e-3b50ef107769
Lewis, Andrew L.
f604ae82-4d54-4f04-ac8f-e7bc6f1f832c
Caine, Marcus
b32f8e4b-3a11-47eb-9600-2eea10e87b8a
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Dreher, Matthew R.
dd5e6291-6a16-4ad2-ae5e-3b50ef107769
Lewis, Andrew L.
f604ae82-4d54-4f04-ac8f-e7bc6f1f832c

Caine, Marcus, Carugo, Dario, Zhang, Xunli, Hill, Martyn, Dreher, Matthew R. and Lewis, Andrew L. (2017) Review of the development of methods for characterization of microspheres for use in embolotherapy: translating Bench to Cathlab. Advanced Healthcare Materials, 6 (9). (doi:10.1002/adhm.201601291).

Record type: Article

Abstract

Therapeutic embolotherapy is the deliberate occlusion of a blood vessel within the body, which can be for the prevention of internal bleeding, stemming of flow through an arteriovenous malformation, or occlusion of blood vessels feeding a tumour. This is achieved using a wide selection of embolic devices such as; balloons, coils, gels, glues and particles.

Particulate embolization is often favoured for blocking smaller vessels, particularly within hyper-vascularised tumours, as they are available in calibrated sizes and can be delivered distally via microcatheters for precise occlusion with associated locoregional drug delivery.

Embolic performance has been traditionally evaluated using animal models, but with increasing interest in the 3R’s (Replacement, Reduction, Refinement), manufacturers, regulators and clinicians have shown interest in the development of more sophisticated in vitro methods for evaluation and prediction of in vivo performance. Herein we review the current progress in developing bespoke techniques incorporating; physical handling, fluid dynamics, occlusive behaviour and sustained drug elution kinetics within vascular systems.

Whilst it is necessary to continue to validate the safety of such devices in vivo, great strides have been made in the development of bench tests that better predict the behaviour of these products aligned with the principles of the 3R’s.

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More information

Accepted/In Press date: 4 January 2017
e-pub ahead of print date: 20 February 2017
Published date: 10 May 2017
Organisations: Bioengineering Group, Mechatronics

Identifiers

Local EPrints ID: 404326
URI: https://eprints.soton.ac.uk/id/eprint/404326
ISSN: 2192-2659
PURE UUID: 08e625bf-2247-4d02-bf65-daf576e7d5f5
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448

Catalogue record

Date deposited: 06 Jan 2017 08:49
Last modified: 06 Jun 2018 13:12

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