OX40: structure and function – what questions remain?
OX40: structure and function – what questions remain?
OX40 is a type 1 transmembrane glycoprotein, reported nearly 30 years ago as a cell surface antigen expressed on activated T cells. Since its discovery, it has been validated as a bone fide costimulatory molecule for T cells and member of the TNF receptor family. However, many questions still remain relating to its function on different T cell sub-sets and with recent interest in its utility as a target for antibody-mediated immunotherapy, there is a growing need to gain a better understanding of its biology.
Here, we review the expression pattern of OX40 and its ligand, discuss the structure of the receptor:ligand interaction, the downstream signalling it can elicit, its function on different T cell subsets and how antibodies might engage with it to provide effective immunotherapy.
13-22
Willoughby, Jane
aa6969bd-3830-4e1b-83ac-6369b5711e1f
Griffiths, Jordana
983022c8-68b3-4b6e-91b2-d228620d8e25
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Cragg, Mark
ec97f80e-f3c8-49b7-a960-20dff648b78c
March 2017
Willoughby, Jane
aa6969bd-3830-4e1b-83ac-6369b5711e1f
Griffiths, Jordana
983022c8-68b3-4b6e-91b2-d228620d8e25
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Cragg, Mark
ec97f80e-f3c8-49b7-a960-20dff648b78c
Willoughby, Jane, Griffiths, Jordana, Tews, Ivo and Cragg, Mark
(2017)
OX40: structure and function – what questions remain?
Molecular Immunology, 83, .
(doi:10.1016/j.molimm.2017.01.006).
Abstract
OX40 is a type 1 transmembrane glycoprotein, reported nearly 30 years ago as a cell surface antigen expressed on activated T cells. Since its discovery, it has been validated as a bone fide costimulatory molecule for T cells and member of the TNF receptor family. However, many questions still remain relating to its function on different T cell sub-sets and with recent interest in its utility as a target for antibody-mediated immunotherapy, there is a growing need to gain a better understanding of its biology.
Here, we review the expression pattern of OX40 and its ligand, discuss the structure of the receptor:ligand interaction, the downstream signalling it can elicit, its function on different T cell subsets and how antibodies might engage with it to provide effective immunotherapy.
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MIMM-D-16-00494R1.pdf
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Text
MIMM-D-16-00494R1.pdf
- Accepted Manuscript
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Accepted/In Press date: 7 January 2017
e-pub ahead of print date: 13 January 2017
Published date: March 2017
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 404511
URI: http://eprints.soton.ac.uk/id/eprint/404511
ISSN: 0161-5890
PURE UUID: 985c4b43-3e98-49b7-870a-618d3d609ffb
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Date deposited: 11 Jan 2017 10:00
Last modified: 16 Mar 2024 04:04
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Author:
Jane Willoughby
Author:
Jordana Griffiths
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