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Impact of yttrium-90 microsphere density, flow dynamics, and administration technique on spatial distribution: analysis using an in vitro model

Impact of yttrium-90 microsphere density, flow dynamics, and administration technique on spatial distribution: analysis using an in vitro model
Impact of yttrium-90 microsphere density, flow dynamics, and administration technique on spatial distribution: analysis using an in vitro model
Purpose: To investigate material density, flow, and viscosity effects on microsphere distribution within an in vitro model designed to simulate hepatic arteries.

Materials and Methods: A vascular flow model was used to compare distribution of glass and resin surrogates in a clinically derived flow range (60–120 mL/min). Blood-mimicking fluid (BMF) composed of glycerol and water (20%–50% vol/vol) was used to simulate a range of blood viscosities. Microsphere distribution was quantified gravimetrically, and injectate solution was dyed to enable quantification by UV spectrophotometry. Microsphere injection rate (5–30 mL/min) and the influence of contrast agent dilution of injection solution (0%–60% vol/vol) were also investigated.

Results: No significant differences in behavior were observed between the glass and resin surrogate materials under any tested flow conditions (P = .182; n = 144 injections). Microspheres tend to align more consistently with the saline injection solution (r2 = 0.5712; n = 144) compared with total BMF flow distribution (r2 = 0.0104; n = 144). The most predictable injectate distribution (ie, greatest alignment with BMF flow, < 5% variation) was demonstrated with > 10-mL/min injection rates of pure saline solution, although < 20% variation with glass microsphere distribution was observed with injection solution containing as much as 30% contrast medium when injected at > 20 mL/min.

Conclusions: Glass and resin yttrium-90 surrogates demonstrated similar distribution in a range of clinically relevant flow conditions, suggesting that microsphere density does not have a significant influence on microsphere distribution. Injection parameters that enhanced the mixing of the spheres with the BMF resulted in the most predictable distribution.



1051-0443
260-268.e2
Caine, Marcus
b32f8e4b-3a11-47eb-9600-2eea10e87b8a
McCafferty, Michael S.
ca9ce7e9-dc6a-44ba-9a29-51407372f797
McGhee, Scott
be19b166-1f29-4f04-8fc6-0ca72de7778b
Garcia, Pedro
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Mullett, Wayne M.
34c3f882-afa6-4f2c-a40f-d3a3097e8750
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Dreher, Matthew R.
dd5e6291-6a16-4ad2-ae5e-3b50ef107769
Lewis, Andrew L.
f604ae82-4d54-4f04-ac8f-e7bc6f1f832c
Caine, Marcus
b32f8e4b-3a11-47eb-9600-2eea10e87b8a
McCafferty, Michael S.
ca9ce7e9-dc6a-44ba-9a29-51407372f797
McGhee, Scott
be19b166-1f29-4f04-8fc6-0ca72de7778b
Garcia, Pedro
edcddaa3-a737-4e2a-badb-4887d6cd5b42
Mullett, Wayne M.
34c3f882-afa6-4f2c-a40f-d3a3097e8750
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Dreher, Matthew R.
dd5e6291-6a16-4ad2-ae5e-3b50ef107769
Lewis, Andrew L.
f604ae82-4d54-4f04-ac8f-e7bc6f1f832c

Caine, Marcus, McCafferty, Michael S., McGhee, Scott, Garcia, Pedro, Mullett, Wayne M., Zhang, Xunli, Hill, Martyn, Dreher, Matthew R. and Lewis, Andrew L. (2017) Impact of yttrium-90 microsphere density, flow dynamics, and administration technique on spatial distribution: analysis using an in vitro model Journal of Vascular and Interventional Radiology, 28, (2), 260-268.e2. (doi:10.1016/j.jvir.2016.07.001).

Record type: Article

Abstract

Purpose: To investigate material density, flow, and viscosity effects on microsphere distribution within an in vitro model designed to simulate hepatic arteries.

Materials and Methods: A vascular flow model was used to compare distribution of glass and resin surrogates in a clinically derived flow range (60–120 mL/min). Blood-mimicking fluid (BMF) composed of glycerol and water (20%–50% vol/vol) was used to simulate a range of blood viscosities. Microsphere distribution was quantified gravimetrically, and injectate solution was dyed to enable quantification by UV spectrophotometry. Microsphere injection rate (5–30 mL/min) and the influence of contrast agent dilution of injection solution (0%–60% vol/vol) were also investigated.

Results: No significant differences in behavior were observed between the glass and resin surrogate materials under any tested flow conditions (P = .182; n = 144 injections). Microspheres tend to align more consistently with the saline injection solution (r2 = 0.5712; n = 144) compared with total BMF flow distribution (r2 = 0.0104; n = 144). The most predictable injectate distribution (ie, greatest alignment with BMF flow, < 5% variation) was demonstrated with > 10-mL/min injection rates of pure saline solution, although < 20% variation with glass microsphere distribution was observed with injection solution containing as much as 30% contrast medium when injected at > 20 mL/min.

Conclusions: Glass and resin yttrium-90 surrogates demonstrated similar distribution in a range of clinically relevant flow conditions, suggesting that microsphere density does not have a significant influence on microsphere distribution. Injection parameters that enhanced the mixing of the spheres with the BMF resulted in the most predictable distribution.



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Accepted/In Press date: 1 July 2016
e-pub ahead of print date: 15 September 2016
Published date: February 2017
Organisations: Bioengineering Group

Identifiers

Local EPrints ID: 405065
URI: http://eprints.soton.ac.uk/id/eprint/405065
ISSN: 1051-0443
PURE UUID: d9f59c44-fbaf-4c3b-a2af-9fad2c1209ca
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448

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Date deposited: 26 Jan 2017 14:31
Last modified: 17 Jul 2017 17:28

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Contributors

Author: Marcus Caine
Author: Michael S. McCafferty
Author: Scott McGhee
Author: Pedro Garcia
Author: Wayne M. Mullett
Author: Xunli Zhang
Author: Martyn Hill ORCID iD
Author: Matthew R. Dreher
Author: Andrew L. Lewis

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