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Clinical and epidemiologic characteristics of hospitalized patients with laboratory-confirmed respiratory syncytial virus infection in eastern china between 2009 and 2013: a retrospective study

Clinical and epidemiologic characteristics of hospitalized patients with laboratory-confirmed respiratory syncytial virus infection in eastern china between 2009 and 2013: a retrospective study
Clinical and epidemiologic characteristics of hospitalized patients with laboratory-confirmed respiratory syncytial virus infection in eastern china between 2009 and 2013: a retrospective study
Respiratory syncytial virus (RSV) is a leading cause of morbidity and mortality worldwide in children aged <5 years and older adults with acute lower respiratory infections (ALRIs). However, few studies regarding the epidemiology of hospitalizations for RSV infection have been performed previously in China. Here, we aimed to describe the clinical and epidemiologic characteristics of hospitalized patients with laboratory-confirmed RSV infection in eastern China. Active surveillance for hospitalized ALRI patients using a broad case definition based on symptoms was performed from 2009-2013 in 12 sentinel hospitals in eastern China. Clinical and epidemiologic data pertaining to hospitalized patients of all ages with laboratory-confirmed RSV infection by PCR assay were collected and analyzed in this study. From 2009 to 2013, 1046 hospitalized patients with laboratory-confirmed RSV infection were enrolled in this study, and 14.7% of patients had subtype A, 24.2% of patients had subtype B, 23.8% of patients with subtype not performed, and 37.3% of patients had RSV coinfections with other viruses. RSV and influenza coinfections (33.3%) were the most common coinfections noted in this study. Moreover, young children aged <5 years (89.1%, 932/1046), particularly young infants aged <1 year (43.3%, 453/1046), represented the highest proportion of patients with RSV infections. In contrast, older adults aged ?60 years (1.1%, 12/1046) represented the lowest proportion of patients with RSV infections among enrolled patients. The peak RSV infection period occurred mainly during autumn and winter, and 57% and 66% of patients exhibited symptoms such as fever (body temperature ?38°C) and cough separately. Additionally, only a small number of patients were treated with broad-spectrum antiviral drugs, and most of patients were treated with antimicrobial drugs that were not appropriate for RSV infection. RSV is a leading viral pathogen and a common cause of viral infection in young children aged <5 years with ALRIs in eastern China. Effective vaccines and antiviral agents targeting RSV are needed to mitigate its large public health impact.
1932-6203
1-12
Schildgen, Oliver
828e902d-44c1-483b-9e6f-269f74d2ce1b
Cui, Dawei
16596789-72c3-47b0-8a5e-2287f661e467
Feng, Luzhao
5842cd78-bfa7-40d1-ae76-92ca4bf70c4d
Chen, Yu
b7c530d5-7aa6-4515-ac71-907f6673423b
Lai, Shengjie
b57a5fe8-cfb6-4fa7-b414-a98bb891b001
Zhang, Zike
85c05276-59dd-4033-82c9-4d33e872906b
Yu, Fei
44e2e05c-7516-4153-ae84-a623d0146484
Zheng, Shufa
76a963cb-dfc7-4331-b6b0-7127cdaea7a5
Li, Zhongjie
f89a98f7-f6d3-4312-995a-bc658ae9a93f
Yu, Hongjie
f6a43c0c-0da8-4124-bd15-cd832d6fee7c
Schildgen, Oliver
828e902d-44c1-483b-9e6f-269f74d2ce1b
Cui, Dawei
16596789-72c3-47b0-8a5e-2287f661e467
Feng, Luzhao
5842cd78-bfa7-40d1-ae76-92ca4bf70c4d
Chen, Yu
b7c530d5-7aa6-4515-ac71-907f6673423b
Lai, Shengjie
b57a5fe8-cfb6-4fa7-b414-a98bb891b001
Zhang, Zike
85c05276-59dd-4033-82c9-4d33e872906b
Yu, Fei
44e2e05c-7516-4153-ae84-a623d0146484
Zheng, Shufa
76a963cb-dfc7-4331-b6b0-7127cdaea7a5
Li, Zhongjie
f89a98f7-f6d3-4312-995a-bc658ae9a93f
Yu, Hongjie
f6a43c0c-0da8-4124-bd15-cd832d6fee7c

Schildgen, Oliver, Cui, Dawei, Feng, Luzhao, Chen, Yu, Lai, Shengjie, Zhang, Zike, Yu, Fei, Zheng, Shufa, Li, Zhongjie and Yu, Hongjie (2016) Clinical and epidemiologic characteristics of hospitalized patients with laboratory-confirmed respiratory syncytial virus infection in eastern china between 2009 and 2013: a retrospective study. PLoS ONE, 11 (11), 1-12. (doi:10.1371/journal.pone.0165437). (PMID:27802292)

Record type: Article

Abstract

Respiratory syncytial virus (RSV) is a leading cause of morbidity and mortality worldwide in children aged <5 years and older adults with acute lower respiratory infections (ALRIs). However, few studies regarding the epidemiology of hospitalizations for RSV infection have been performed previously in China. Here, we aimed to describe the clinical and epidemiologic characteristics of hospitalized patients with laboratory-confirmed RSV infection in eastern China. Active surveillance for hospitalized ALRI patients using a broad case definition based on symptoms was performed from 2009-2013 in 12 sentinel hospitals in eastern China. Clinical and epidemiologic data pertaining to hospitalized patients of all ages with laboratory-confirmed RSV infection by PCR assay were collected and analyzed in this study. From 2009 to 2013, 1046 hospitalized patients with laboratory-confirmed RSV infection were enrolled in this study, and 14.7% of patients had subtype A, 24.2% of patients had subtype B, 23.8% of patients with subtype not performed, and 37.3% of patients had RSV coinfections with other viruses. RSV and influenza coinfections (33.3%) were the most common coinfections noted in this study. Moreover, young children aged <5 years (89.1%, 932/1046), particularly young infants aged <1 year (43.3%, 453/1046), represented the highest proportion of patients with RSV infections. In contrast, older adults aged ?60 years (1.1%, 12/1046) represented the lowest proportion of patients with RSV infections among enrolled patients. The peak RSV infection period occurred mainly during autumn and winter, and 57% and 66% of patients exhibited symptoms such as fever (body temperature ?38°C) and cough separately. Additionally, only a small number of patients were treated with broad-spectrum antiviral drugs, and most of patients were treated with antimicrobial drugs that were not appropriate for RSV infection. RSV is a leading viral pathogen and a common cause of viral infection in young children aged <5 years with ALRIs in eastern China. Effective vaccines and antiviral agents targeting RSV are needed to mitigate its large public health impact.

Other
2016- PLoS One- Clinical and Epidemiologic Characteristics of Hospitalized Patients with Laboratory-Confirmed Respiratory Syncytial Virus Infection in Eastern China between 2009 and 2013.PDF - Version of Record
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More information

Accepted/In Press date: 11 October 2016
e-pub ahead of print date: 1 November 2016
Published date: 1 November 2016
Organisations: WorldPop, Population, Health & Wellbeing (PHeW)

Identifiers

Local EPrints ID: 405111
URI: https://eprints.soton.ac.uk/id/eprint/405111
ISSN: 1932-6203
PURE UUID: 8d1e9c57-9e44-41af-abab-c14d57055a8f
ORCID for Shengjie Lai: ORCID iD orcid.org/0000-0001-9781-8148

Catalogue record

Date deposited: 27 Jan 2017 10:16
Last modified: 15 Aug 2019 00:22

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