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Highly enantioselective synthesis of alkylpyridine derivatives through a Michael/Michael/Aldol cascade reaction

Highly enantioselective synthesis of alkylpyridine derivatives through a Michael/Michael/Aldol cascade reaction
Highly enantioselective synthesis of alkylpyridine derivatives through a Michael/Michael/Aldol cascade reaction
A method for the synthesis of pyridine derivativesbased on a triple cascade reaction catalyzed by chiral secondaryamines was developed. The resulting cyclohexenes (three C–C bonds were formed) were obtained in good yields with good diastereoselectivities and excellent enantioselectivities.
719-725
Meazza, Marta
c4665645-8c77-4cfd-aa02-6bcc3341c1aa
Potter, Michael
90277857-5e0c-4e5f-812d-7263eb0070b9
Pitak, Mateusz
eeb6a00f-2291-4376-830f-d30dfd607ed1
Coles, Simon
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Mazzanti, Andrea
1e31a7a1-e163-4bd4-9e72-42bc64f60277
Rios Torres, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Meazza, Marta
c4665645-8c77-4cfd-aa02-6bcc3341c1aa
Potter, Michael
90277857-5e0c-4e5f-812d-7263eb0070b9
Pitak, Mateusz
eeb6a00f-2291-4376-830f-d30dfd607ed1
Coles, Simon
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Mazzanti, Andrea
1e31a7a1-e163-4bd4-9e72-42bc64f60277
Rios Torres, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441

Meazza, Marta, Potter, Michael, Pitak, Mateusz, Coles, Simon, Mazzanti, Andrea and Rios Torres, Ramon (2017) Highly enantioselective synthesis of alkylpyridine derivatives through a Michael/Michael/Aldol cascade reaction. European Journal of Organic Chemistry, 2017 (03), 719-725. (doi:10.1002/ejoc.201601491).

Record type: Article

Abstract

A method for the synthesis of pyridine derivativesbased on a triple cascade reaction catalyzed by chiral secondaryamines was developed. The resulting cyclohexenes (three C–C bonds were formed) were obtained in good yields with good diastereoselectivities and excellent enantioselectivities.

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Accepted/In Press date: 29 November 2016
e-pub ahead of print date: 24 January 2017
Organisations: Faculty of Natural and Environmental Sciences

Identifiers

Local EPrints ID: 405743
URI: http://eprints.soton.ac.uk/id/eprint/405743
PURE UUID: 412cd217-daeb-4609-8437-d8d28719a368
ORCID for Marta Meazza: ORCID iD orcid.org/0000-0003-4382-0626
ORCID for Mateusz Pitak: ORCID iD orcid.org/0000-0002-3680-7100
ORCID for Simon Coles: ORCID iD orcid.org/0000-0001-8414-9272
ORCID for Ramon Rios Torres: ORCID iD orcid.org/0000-0002-3843-8521

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Date deposited: 18 Feb 2017 00:21
Last modified: 08 Oct 2020 04:26

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