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What do we know about the inflammasome in humans?

What do we know about the inflammasome in humans?
What do we know about the inflammasome in humans?
The inflammasome complex is part of the innate immune system, which serves to protect the host against harm from pathogens and damaged cells. It is a term first proposed by Tschopp's group in 2002, with numerous original research articles and reviews published on the topic since. There have been many types of inflammasome identified, but all result in the common pathway of activation of caspases and interleukin 1? along with possible cell death due to pyroptosis. Despite a growing body of research investigating the structure and function of the inflammasome in animal models, there is still limited evidence identifying inflammasome components in human physiology and disease. In this review, we explore the molecular structure and mechanism of activation of the inflammasome with a particular focus on inflammasome complexes expressed in humans. Inflammasome components have been identified in several human peripheral and brain tissues using both in-vivo and ex-vivo work, and the inflammasome complex has been shown to be associated with several genetic and acquired inflammatory disorders. We discuss the strengths and weaknesses of the information available on the inflammasome with an emphasis on the importance of prioritising work on human tissue. There is a huge demand for more effective treatments for a number of inflammatory and neurodegenerative diseases. Modulation of the inflammasome has been proposed as a novel treatment for several of these diseases and there are currently clinical trials ongoing to test this theory.
192-204
Amin, Jay
692a8880-70ff-4b64-a7e9-7d0d53449a30
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Rakic, Sonja
a6631393-7e52-4df4-a936-00cd2df5b6d4
Amin, Jay
692a8880-70ff-4b64-a7e9-7d0d53449a30
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Rakic, Sonja
a6631393-7e52-4df4-a936-00cd2df5b6d4

Amin, Jay, Boche, Delphine and Rakic, Sonja (2017) What do we know about the inflammasome in humans? Brain Pathology, 27, (2), pp. 192-204. (doi:10.1111/bpa.12479). (PMID:27997042).

Record type: Article

Abstract

The inflammasome complex is part of the innate immune system, which serves to protect the host against harm from pathogens and damaged cells. It is a term first proposed by Tschopp's group in 2002, with numerous original research articles and reviews published on the topic since. There have been many types of inflammasome identified, but all result in the common pathway of activation of caspases and interleukin 1? along with possible cell death due to pyroptosis. Despite a growing body of research investigating the structure and function of the inflammasome in animal models, there is still limited evidence identifying inflammasome components in human physiology and disease. In this review, we explore the molecular structure and mechanism of activation of the inflammasome with a particular focus on inflammasome complexes expressed in humans. Inflammasome components have been identified in several human peripheral and brain tissues using both in-vivo and ex-vivo work, and the inflammasome complex has been shown to be associated with several genetic and acquired inflammatory disorders. We discuss the strengths and weaknesses of the information available on the inflammasome with an emphasis on the importance of prioritising work on human tissue. There is a huge demand for more effective treatments for a number of inflammatory and neurodegenerative diseases. Modulation of the inflammasome has been proposed as a novel treatment for several of these diseases and there are currently clinical trials ongoing to test this theory.

PDF PAPERS_2017 Brain Pathology mini-symposium_Boche_bpa12479.pdf - Accepted Manuscript
Restricted to Repository staff only until 20 February 2018.

More information

Accepted/In Press date: 6 December 2016
e-pub ahead of print date: 20 February 2017
Published date: March 2017
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 405772
URI: http://eprints.soton.ac.uk/id/eprint/405772
PURE UUID: 3677d822-5c69-41a4-8345-841e9e16c565
ORCID for Delphine Boche: ORCID iD orcid.org/0000-0002-5884-130X

Catalogue record

Date deposited: 18 Feb 2017 00:20
Last modified: 17 Jul 2017 14:07

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Contributors

Author: Jay Amin
Author: Delphine Boche ORCID iD
Author: Sonja Rakic

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