The University of Southampton
University of Southampton Institutional Repository

Clinical and cost effectiveness of left ventricular assist devices as a bridge to heart transplantation for people with end stage heart failure: a systematic review and economic evaluation

Clegg, Andrew J., Scott, David A., Loveman, Emma, Colquitt, Jill L., Royle, Pam and Bryant, Jackie (2006) Clinical and cost effectiveness of left ventricular assist devices as a bridge to heart transplantation for people with end stage heart failure: a systematic review and economic evaluation European Heart Journal, 27, (24), pp. 2929-2938. (doi:10.1093/eurheartj/ehi857).

Record type: Article

Abstract

Aims To evaluate the clinical and cost-effectiveness of left ventricular (LV) assist devices (LVADs) as a bridge to transplant (BTT) for people with end-stage heart failure (ESHF) through a systematic review and economic evaluation.
Methods and results The systematic review and economic evaluation was conducted according to internationally recognized methods. The search strategy identified systematic reviews, randomized controlled trials, quasi-experimental studies, and observational studies evaluating the effects of LVADs on survival, functional capacity, and quality of life.
Cost-effectiveness was assessed through a 5-year decision analytic model to estimate the incremental cost-effectiveness ratio of LVADs compared with usual care. Despite the poor methodological quality of the 18 studies included, LVADs appear beneficial improving survival, functional status, and quality of life. Adverse events are a serious concern.
The economic evaluation showed that LVADs had a cost per quality adjusted life year of £65 242 (95% confidence interval £34 194--364 564). Sensitivity analysis showed that post-heart transplant survival gains, pre-heart transplant patient utility, and one-off costs associated with implantation determine cost-effectiveness.
Conclusion Although LVADs appear clinically effective as a BTT for people with ESHF, it is unlikely that they will be cost-effective unless costs decrease or the benefits of their use increase.

Full text not available from this repository.

More information

Published date: 2006
Keywords: heart failure, left ventricular assist devices, systematic review, economic evaluation, health technology assessment

Identifiers

Local EPrints ID: 40611
URI: http://eprints.soton.ac.uk/id/eprint/40611
ISSN: 0195-668X
PURE UUID: 1073ff74-3a41-4579-aaeb-3c9fe6a3bcb0

Catalogue record

Date deposited: 06 Jul 2006
Last modified: 17 Jul 2017 15:33

Export record

Altmetrics

Contributors

Author: Andrew J. Clegg
Author: David A. Scott
Author: Emma Loveman
Author: Pam Royle
Author: Jackie Bryant

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×