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Maternal stress and psychological distress preconception: association with offspring atopic eczema at age 12 months

Maternal stress and psychological distress preconception: association with offspring atopic eczema at age 12 months
Maternal stress and psychological distress preconception: association with offspring atopic eczema at age 12 months

BACKGROUND: Perinatal maternal stress and low mood have been linked to offspring atopic eczema.

OBJECTIVES: To examine the relation of maternal stress/mood with atopic eczema in the offspring, focusing particularly on stress/psychological distress preconception.

METHODS: At recruitment in the UK Southampton Women's Survey, preconception maternal reports of perceived stress in daily living and the effect of stress on health were recorded; in a subsample, psychological distress was assessed (12-item General Health Questionnaire). Infants were followed up at ages 6 (n = 2956) and 12 (n = 2872) months and atopic eczema ascertained (based on UK Working Party Criteria for the Definition of Atopic Dermatitis). At 6 months post-partum, mothers were asked if they had experienced symptoms of low mood since childbirth and completed the Edinburgh Postnatal Depression Scale.

RESULTS: Preconception perceived stress affecting health [OR 1.21 (95% CI 1.08-1.35), P = 0.001] and stress in daily living [OR 1.16 (1.03-1.30), P = 0.014] were associated with an increased risk of offspring atopic eczema at age 12 months but not at 6 months, robust to adjustment for potentially confounding variables. Findings were similar for maternal psychological distress preconception. Low maternal mood between delivery and 6 months post-partum was associated with an increased risk of infantile atopic eczema at age 12 months, but no significant association between post-natal mood and atopic eczema was seen after taking account of preconception stress.

CONCLUSION AND CLINICAL RELEVANCE: Our data provide novel evidence linking maternal stress at preconception to atopic eczema risk, supporting a developmental contribution to the aetiology of atopic eczema and pointing to potentially modifiable influences.

Adult, Child, Child, Preschool, Dermatitis, Atopic, Female, Humans, Infant, Infant, Newborn, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Stress, Psychological, Surveys and Questionnaires, Journal Article
0954-7894
760-769
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Crozier, Sarah
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Baird, Janis
f4bf2039-6118-436f-ab69-df8b4d17f824
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Southampton Women's Study Group
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Crozier, Sarah
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Baird, Janis
f4bf2039-6118-436f-ab69-df8b4d17f824
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd

El-Heis, Sarah, Crozier, Sarah, Healy, Eugene, Robinson, Sian, Harvey, Nicholas, Cooper, Cyrus, Inskip, Hazel, Baird, Janis and Godfrey, Keith , Southampton Women's Study Group (2017) Maternal stress and psychological distress preconception: association with offspring atopic eczema at age 12 months. Clinical & Experimental Allergy, 47 (6), 760-769. (doi:10.1111/cea.12910).

Record type: Article

Abstract

BACKGROUND: Perinatal maternal stress and low mood have been linked to offspring atopic eczema.

OBJECTIVES: To examine the relation of maternal stress/mood with atopic eczema in the offspring, focusing particularly on stress/psychological distress preconception.

METHODS: At recruitment in the UK Southampton Women's Survey, preconception maternal reports of perceived stress in daily living and the effect of stress on health were recorded; in a subsample, psychological distress was assessed (12-item General Health Questionnaire). Infants were followed up at ages 6 (n = 2956) and 12 (n = 2872) months and atopic eczema ascertained (based on UK Working Party Criteria for the Definition of Atopic Dermatitis). At 6 months post-partum, mothers were asked if they had experienced symptoms of low mood since childbirth and completed the Edinburgh Postnatal Depression Scale.

RESULTS: Preconception perceived stress affecting health [OR 1.21 (95% CI 1.08-1.35), P = 0.001] and stress in daily living [OR 1.16 (1.03-1.30), P = 0.014] were associated with an increased risk of offspring atopic eczema at age 12 months but not at 6 months, robust to adjustment for potentially confounding variables. Findings were similar for maternal psychological distress preconception. Low maternal mood between delivery and 6 months post-partum was associated with an increased risk of infantile atopic eczema at age 12 months, but no significant association between post-natal mood and atopic eczema was seen after taking account of preconception stress.

CONCLUSION AND CLINICAL RELEVANCE: Our data provide novel evidence linking maternal stress at preconception to atopic eczema risk, supporting a developmental contribution to the aetiology of atopic eczema and pointing to potentially modifiable influences.

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More information

Accepted/In Press date: 9 February 2017
e-pub ahead of print date: 17 March 2017
Published date: June 2017
Additional Information: © 2017 John Wiley & Sons Ltd.
Keywords: Adult, Child, Child, Preschool, Dermatitis, Atopic, Female, Humans, Infant, Infant, Newborn, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Stress, Psychological, Surveys and Questionnaires, Journal Article
Organisations: Medical Research Council, Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 406268
URI: https://eprints.soton.ac.uk/id/eprint/406268
ISSN: 0954-7894
PURE UUID: cf36f43f-d5c4-49c7-bd00-9121f65bd059
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Sian Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Janis Baird: ORCID iD orcid.org/0000-0002-4039-4361
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 10 Mar 2017 10:43
Last modified: 10 Dec 2019 06:11

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