Overall treatment time and the conventional arm of the CHART trial in the radiotherapy of head and neck cancer
Overall treatment time and the conventional arm of the CHART trial in the radiotherapy of head and neck cancer
BACKGROUND AND PURPOSE: An analysis of the 366 patients treated with conventional radiotherapy in the CHART randomized trial was performed to determine whether prolongation of treatment time had any influence on tumour control or survival and to assess if this could have influenced the results of the randomized comparison of CHART against conventional radiotherapy.
METHOD: After a preliminary analysis the cases were divided into two groups according to duration of treatment.
RESULTS: Survival and primary tumour control showed small margins of deterioration when the 232 patients who had been treated up to 48 days were compared with 127 patients who had been treated in 49 or more days. These differences were not large with an estimated difference in 2-year survival of 8% and not conventionally statistically significant (P=0.25); furthermore, the survival difference was considerably reduced when the prognostic factors were taken into consideration in a Cox model.
CONCLUSION: With a mean difference in treatment duration of 5.8 days, the marginal differences observed between patients treated for longer and shorter times are compatible with that which has been suggested in previous publications for the prolongation of treatment time in head and neck cancer. We conclude that the randomized comparison of CHART with conventional radiotherapy is unlikely to be affected by conventionally treated patients who took longer than 48 days to complete their treatment.
Carcinoma, Squamous Cell, Confidence Intervals, Dose Fractionation, Female, Head and Neck Neoplasms, Humans, Male, Odds Ratio, Prognosis, Proportional Hazards Models, Radiotherapy Dosage, Remission Induction, Survival Rate, Time Factors, Treatment Outcome, Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial
25-28
Robertson, Gerry
d64eff37-2d4d-47c1-a6ee-11b04836ee90
Parmar, Mahesh
5574463d-506e-499e-9381-6130f1ef7dbe
Foy, Chris
f0927bac-894e-47a8-b5eb-7c1b4e40b9a6
Griffiths, Gareth
7fd300c0-d279-4ff6-842d-aa1f2b9b864d
Saunders, Michele
30b96a6f-b9e3-47e9-9731-4636ec804d42
Dische, Stanley
5ae3a621-2a29-44b9-b6db-9fdd9fea4e17
January 1999
Robertson, Gerry
d64eff37-2d4d-47c1-a6ee-11b04836ee90
Parmar, Mahesh
5574463d-506e-499e-9381-6130f1ef7dbe
Foy, Chris
f0927bac-894e-47a8-b5eb-7c1b4e40b9a6
Griffiths, Gareth
7fd300c0-d279-4ff6-842d-aa1f2b9b864d
Saunders, Michele
30b96a6f-b9e3-47e9-9731-4636ec804d42
Dische, Stanley
5ae3a621-2a29-44b9-b6db-9fdd9fea4e17
Robertson, Gerry, Parmar, Mahesh, Foy, Chris, Griffiths, Gareth, Saunders, Michele and Dische, Stanley
(1999)
Overall treatment time and the conventional arm of the CHART trial in the radiotherapy of head and neck cancer.
Radiotherapy and Oncology, 50 (1), .
(doi:10.1016/S0167-8140(98)00116-9).
Abstract
BACKGROUND AND PURPOSE: An analysis of the 366 patients treated with conventional radiotherapy in the CHART randomized trial was performed to determine whether prolongation of treatment time had any influence on tumour control or survival and to assess if this could have influenced the results of the randomized comparison of CHART against conventional radiotherapy.
METHOD: After a preliminary analysis the cases were divided into two groups according to duration of treatment.
RESULTS: Survival and primary tumour control showed small margins of deterioration when the 232 patients who had been treated up to 48 days were compared with 127 patients who had been treated in 49 or more days. These differences were not large with an estimated difference in 2-year survival of 8% and not conventionally statistically significant (P=0.25); furthermore, the survival difference was considerably reduced when the prognostic factors were taken into consideration in a Cox model.
CONCLUSION: With a mean difference in treatment duration of 5.8 days, the marginal differences observed between patients treated for longer and shorter times are compatible with that which has been suggested in previous publications for the prolongation of treatment time in head and neck cancer. We conclude that the randomized comparison of CHART with conventional radiotherapy is unlikely to be affected by conventionally treated patients who took longer than 48 days to complete their treatment.
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Published date: January 1999
Keywords:
Carcinoma, Squamous Cell, Confidence Intervals, Dose Fractionation, Female, Head and Neck Neoplasms, Humans, Male, Odds Ratio, Prognosis, Proportional Hazards Models, Radiotherapy Dosage, Remission Induction, Survival Rate, Time Factors, Treatment Outcome, Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial
Organisations:
Clinical Trials Unit
Identifiers
Local EPrints ID: 406316
URI: http://eprints.soton.ac.uk/id/eprint/406316
ISSN: 0167-8140
PURE UUID: d0222ac1-d269-45c9-9ed6-bf7b45161c04
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Date deposited: 10 Mar 2017 10:44
Last modified: 16 Mar 2024 04:19
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Author:
Gerry Robertson
Author:
Mahesh Parmar
Author:
Chris Foy
Author:
Michele Saunders
Author:
Stanley Dische
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