A minimum core outcome dataset for the reporting of preclinical chemotherapeutic drug studies: Lessons learned from multiple discordant methodologies in the setting of colorectal cancer
A minimum core outcome dataset for the reporting of preclinical chemotherapeutic drug studies: Lessons learned from multiple discordant methodologies in the setting of colorectal cancer
In vivo studies in animal models are critical tools necessary to study the fundamental complexity of carcinogenesis. A constant strive to improve animal models in cancer exists, especially those investigating the use of chemotherapeutic effectiveness. In the present systematic review, colorectal cancer (CRC) is used as an example to highlight and critically evaluate the range of reporting strategies used when investigating chemotherapeutic agents in the preclinical setting. A systematic review examining the methodology and reporting of preclinical chemotherapeutic drug studies using CRC murine models was conducted. A total of 45 studies were included in this systematic review. The literature was found to be highly heterogeneous with various cell lines, animal strains, animal ages and chemotherapeutic compounds/regimens tested, proving difficult to compare outcomes between similar studies or indeed gain any significant insight into which chemotherapeutic regimen caused adverse events. From this analysis we propose a minimum core outcome dataset that could be regarded as a standardised way of reporting results from in vivo experimentation.
80-102
West, M.A.
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Roman, A.
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Sayan, E.
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Primrose, J.N.
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Wedge, S.R.
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Underwood, T.J.
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Mirnezami, A.H.
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April 2017
West, M.A.
98b67e58-9875-4133-b236-8a10a0a12c04
Roman, A.
cc7d1a8e-5f84-4768-be04-626ded24f538
Sayan, E.
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Primrose, J.N.
d85f3b28-24c6-475f-955b-ec457a3f9185
Wedge, S.R.
8ea95b32-9103-4656-8e2d-ecbdf9d389ee
Underwood, T.J.
8e81bf60-edd2-4b0e-8324-3068c95ea1c6
Mirnezami, A.H.
b3c7aee7-46a4-404c-bfe3-f72388e0bc94
West, M.A., Roman, A., Sayan, E., Primrose, J.N., Wedge, S.R., Underwood, T.J. and Mirnezami, A.H.
(2017)
A minimum core outcome dataset for the reporting of preclinical chemotherapeutic drug studies: Lessons learned from multiple discordant methodologies in the setting of colorectal cancer.
Critical Reviews in Oncology/Hematology, 112, .
(doi:10.1016/j.critrevonc.2017.02.008).
Abstract
In vivo studies in animal models are critical tools necessary to study the fundamental complexity of carcinogenesis. A constant strive to improve animal models in cancer exists, especially those investigating the use of chemotherapeutic effectiveness. In the present systematic review, colorectal cancer (CRC) is used as an example to highlight and critically evaluate the range of reporting strategies used when investigating chemotherapeutic agents in the preclinical setting. A systematic review examining the methodology and reporting of preclinical chemotherapeutic drug studies using CRC murine models was conducted. A total of 45 studies were included in this systematic review. The literature was found to be highly heterogeneous with various cell lines, animal strains, animal ages and chemotherapeutic compounds/regimens tested, proving difficult to compare outcomes between similar studies or indeed gain any significant insight into which chemotherapeutic regimen caused adverse events. From this analysis we propose a minimum core outcome dataset that could be regarded as a standardised way of reporting results from in vivo experimentation.
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1-s2.0-S1040842816302979-main
- Accepted Manuscript
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Accepted/In Press date: 13 February 2017
e-pub ahead of print date: 16 February 2017
Published date: April 2017
Organisations:
Cancer Sciences
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Local EPrints ID: 406348
URI: http://eprints.soton.ac.uk/id/eprint/406348
ISSN: 1040-8428
PURE UUID: 3e176fec-bdd4-40b6-be31-be1f525ebecd
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Date deposited: 10 Mar 2017 10:45
Last modified: 11 May 2024 04:01
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Author:
A. Roman
Author:
S.R. Wedge
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