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Randomised controlled trial of cognitive-behavioural therapy in early schizophrenia: acute-phase outcomes

Randomised controlled trial of cognitive-behavioural therapy in early schizophrenia: acute-phase outcomes
Randomised controlled trial of cognitive-behavioural therapy in early schizophrenia: acute-phase outcomes
Background: Cognitive—behavioural therapy (CBT) improves persistent psychotic symptoms.
Aims: To test the effectiveness of added CBT in accelerating remission from acute psychotic symptoms in early schizophrenia.
Method: A 5-week CBT programme plus routine care was compared with supportive counselling plus routine care and routine care alone in a multi-centre trial randomising 315 people with DSM—IV schizophrenia and related disorders in their first (83%) or second acute admission. Outcome assessments were blinded.
Results: Linear regression over 70 days showed predicted trends towards faster improvement in the CBT group.
Uncorrected univariate comparisons showed significant benefits at 4 but not 6 weeks for CBTv. routine care alone on Positive and Negative Syndrome Scale total and positive sub-scale scores and delusion score and benefits v. supportive counselling for auditory hallucinations score.
Conclusions: CBT shows transient advantages over routine care alone or supportive counselling in speeding remission from acute symptoms in early schizophrenia.
0007-1250
s91-s97
Lewis, Shôn
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Tarrier, Nicholas
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Haddock, Gillian
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Bentall, Richard
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Kinderman, Peter
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Kingdon, David
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Siddle, Ronald
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Drake, Richard
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Everitt, Julie
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Leadley, Karen
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Benn, Andy
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Grazebrook, Katy
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Haley, Cliff
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Akhtar, Shahid
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Davies, Linda
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Palmer, Steve
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Faragher, Brian
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Dunn, Graham
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Lewis, Shôn
cf54165f-32db-4bcb-b619-9d452294690f
Tarrier, Nicholas
15550ee2-1e53-4f30-98e3-b70b12cbe683
Haddock, Gillian
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Bentall, Richard
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Kinderman, Peter
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Kingdon, David
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Siddle, Ronald
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Drake, Richard
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Everitt, Julie
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Leadley, Karen
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Benn, Andy
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Grazebrook, Katy
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Haley, Cliff
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Akhtar, Shahid
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Davies, Linda
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Palmer, Steve
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Faragher, Brian
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Dunn, Graham
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Lewis, Shôn, Tarrier, Nicholas, Haddock, Gillian, Bentall, Richard, Kinderman, Peter, Kingdon, David, Siddle, Ronald, Drake, Richard, Everitt, Julie, Leadley, Karen, Benn, Andy, Grazebrook, Katy, Haley, Cliff, Akhtar, Shahid, Davies, Linda, Palmer, Steve, Faragher, Brian and Dunn, Graham (2002) Randomised controlled trial of cognitive-behavioural therapy in early schizophrenia: acute-phase outcomes. British Journal of Psychiatry, 181 (Supplement 43), s91-s97.

Record type: Article

Abstract

Background: Cognitive—behavioural therapy (CBT) improves persistent psychotic symptoms.
Aims: To test the effectiveness of added CBT in accelerating remission from acute psychotic symptoms in early schizophrenia.
Method: A 5-week CBT programme plus routine care was compared with supportive counselling plus routine care and routine care alone in a multi-centre trial randomising 315 people with DSM—IV schizophrenia and related disorders in their first (83%) or second acute admission. Outcome assessments were blinded.
Results: Linear regression over 70 days showed predicted trends towards faster improvement in the CBT group.
Uncorrected univariate comparisons showed significant benefits at 4 but not 6 weeks for CBTv. routine care alone on Positive and Negative Syndrome Scale total and positive sub-scale scores and delusion score and benefits v. supportive counselling for auditory hallucinations score.
Conclusions: CBT shows transient advantages over routine care alone or supportive counselling in speeding remission from acute symptoms in early schizophrenia.

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More information

Published date: September 2002
Additional Information: Presented in part at the European First Episode Schizophrenia Network Meeting, Whistler BC, Canada, 28 April 2001

Identifiers

Local EPrints ID: 40637
URI: http://eprints.soton.ac.uk/id/eprint/40637
ISSN: 0007-1250
PURE UUID: a88b06cc-9040-4e36-a3ff-5f1735f7a1b4

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Date deposited: 07 Jul 2006
Last modified: 15 Mar 2024 08:21

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Contributors

Author: Shôn Lewis
Author: Nicholas Tarrier
Author: Gillian Haddock
Author: Richard Bentall
Author: Peter Kinderman
Author: David Kingdon
Author: Ronald Siddle
Author: Richard Drake
Author: Julie Everitt
Author: Karen Leadley
Author: Andy Benn
Author: Katy Grazebrook
Author: Cliff Haley
Author: Shahid Akhtar
Author: Linda Davies
Author: Steve Palmer
Author: Brian Faragher
Author: Graham Dunn

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