The University of Southampton
University of Southampton Institutional Repository

Perfusion magnetic resonance abnormalities in patients with sickle cell disease

Record type: Article

Neurological complications are common in sickle cell disease (SCD). However, it is often difficult to relate the clinical presentation to conventional neuroimaging, because subclinical infarction is common and stroke has been described in the absence of large-vessel disease. We studied 48 patients with SCD aged 4-34 (median 13) years with T2-weighted, diffusion and perfusion magnetic resonance imaging (MRI) and with MR angiography. Forty-four underwent transcranial Doppler (TCD). Abnormalities on perfusion imaging were seen in 25 cases, 24 of whom had been symptomatic. The remaining patient had evidence of executive dysfunction and reduced perfusion in the frontal lobes. The perfusion abnormality was larger than the area of infarction in 9 patients and was seen in an arterial distribution with no infarction in a further 9. In 3 patients with transient ischemic attacks, perfusion abnormalities were demonstrated in the absence of any other neuroimaging abnormalities, and perfusion changes were seen in 3 others despite normal MR angiography and TCD. Perfusion abnormalities are associated with neurological symptoms in patients with SCD, whether or not MRI, MR angiography, and TCD are abnormal. It is likely that this technique will guide management in individual patients

Full text not available from this repository.

Citation

Kirkham, Fenella J., Calamante, Fernando, Bynevelt, Michael, Gadian, David G., Evans, Jane P.M., Cox, Timothy C. and Connolly, Alan (2001) Perfusion magnetic resonance abnormalities in patients with sickle cell disease Annals of Neurology, 49, (4), pp. 477-485. (doi:10.1002/ana.97).

More information

Published date: 2001

Identifiers

Local EPrints ID: 40641
URI: http://eprints.soton.ac.uk/id/eprint/40641
ISSN: 0364-5134
PURE UUID: 435782e6-ffa8-47d3-9236-ac36628e3635

Catalogue record

Date deposited: 07 Jul 2006
Last modified: 16 Apr 2017 21:51

Export record

Altmetrics

Contributors

Author: Fenella J. Kirkham
Author: Fernando Calamante
Author: Michael Bynevelt
Author: David G. Gadian
Author: Jane P.M. Evans
Author: Timothy C. Cox
Author: Alan Connolly

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×