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Investigation of risk factors in children with arterial ischemic stroke

Investigation of risk factors in children with arterial ischemic stroke
Investigation of risk factors in children with arterial ischemic stroke
We present data on the known risk factors encountered in children presenting with a first arterial ischemic stroke to a single tertiary center over 22 years. Two hundred twelve patients (54% male; median age, 5 years) were identified. One hundred fifteen (54%) were previously healthy. Cerebral arterial imaging was undertaken in 185 patients (87%) and was abnormal in 79%. Of 104 previously healthy patients investigated with echocardiography, only 8 had abnormal studies. Genetic or acquired conditions causing thrombophilia were rare. Forty percent of patients were anemic, and 21% either had elevated total plasma homocysteine or were homozygous for the t-MTHFR mutation. Trauma and previous varicella zoster infection were significantly more common in the previously healthy group. There was a significant association between cerebral arterial abnormalities and systolic blood pressure greater than 90th percentile and a trend for an association with varicella within the previous year. Clinical history and examination usually identify underlying risk factors and precipitating triggers for arterial ischemic stroke in childhood. Cerebral arterial imaging is usually abnormal, but echocardiography and prothrombotic screening are commonly negative.
0364-5134
167-173
Ganesan, Vijeya
e3ae2ff5-0d89-43d2-8275-ba35b717149d
Prengler, Mara
6f2b4ccb-c630-406e-9df2-55147ccc7f5a
McShane, Michael A.
b15a2629-c057-49ad-9826-3b800227b373
Wade, Angela M.
0616f783-24e3-48b1-9245-ed961c68d109
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Ganesan, Vijeya
e3ae2ff5-0d89-43d2-8275-ba35b717149d
Prengler, Mara
6f2b4ccb-c630-406e-9df2-55147ccc7f5a
McShane, Michael A.
b15a2629-c057-49ad-9826-3b800227b373
Wade, Angela M.
0616f783-24e3-48b1-9245-ed961c68d109
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58

Ganesan, Vijeya, Prengler, Mara, McShane, Michael A., Wade, Angela M. and Kirkham, Fenella J. (2003) Investigation of risk factors in children with arterial ischemic stroke. Annals of Neurology, 53 (2), 167-173. (doi:10.1002/ana.10423).

Record type: Article

Abstract

We present data on the known risk factors encountered in children presenting with a first arterial ischemic stroke to a single tertiary center over 22 years. Two hundred twelve patients (54% male; median age, 5 years) were identified. One hundred fifteen (54%) were previously healthy. Cerebral arterial imaging was undertaken in 185 patients (87%) and was abnormal in 79%. Of 104 previously healthy patients investigated with echocardiography, only 8 had abnormal studies. Genetic or acquired conditions causing thrombophilia were rare. Forty percent of patients were anemic, and 21% either had elevated total plasma homocysteine or were homozygous for the t-MTHFR mutation. Trauma and previous varicella zoster infection were significantly more common in the previously healthy group. There was a significant association between cerebral arterial abnormalities and systolic blood pressure greater than 90th percentile and a trend for an association with varicella within the previous year. Clinical history and examination usually identify underlying risk factors and precipitating triggers for arterial ischemic stroke in childhood. Cerebral arterial imaging is usually abnormal, but echocardiography and prothrombotic screening are commonly negative.

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Published date: 2003

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Local EPrints ID: 40642
URI: http://eprints.soton.ac.uk/id/eprint/40642
ISSN: 0364-5134
PURE UUID: 19da1b84-3448-43f1-89e2-511b0a0077d7
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 07 Jul 2006
Last modified: 16 Mar 2024 03:22

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Contributors

Author: Vijeya Ganesan
Author: Mara Prengler
Author: Michael A. McShane
Author: Angela M. Wade

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