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Clinical evidence of the multifactorial nature of diabetic macular edema

Clinical evidence of the multifactorial nature of diabetic macular edema
Clinical evidence of the multifactorial nature of diabetic macular edema
Purpose: To report functional and morphologic outcomes, based on diabetic macular edema (DME) chronicity and baseline best-corrected visual acuity (BCVA), from a subanalysis of the fluocinolone acetonide for macular edema (FAME) trials.Methods: Patients were categorized by DME duration (nonchronic [ncDME] or chronic [cDME] DME) and three nonexclusive baseline vision strata. Anatomic and visual acuity VA outcomes of these cohorts were compared with treatment assignment.Results: For all patients with ncDME and cDME who received sham control, 27.8% and 13.4%, respectively, gained >=15 BCVA letters, whereas 22.3% and 34.0% of 0.2 [mu]g/day fluocinolone acetonide (FAc)-treated patients, respectively, gained >=15 BCVA letters. Among patients with ncDME who received sham control, as baseline vision decreased, the percentage gaining >=15 BCVA letters increased; however, among those with cDME, the percentage gaining >=15 BCVA letters did not change as baseline vision decreased. Conversely, among 0.2 [mu]g/day FAc-treated patients, the percentage gaining >=15 BCVA letters increased with decreasing baseline vision, regardless of DME chronicity. Anatomical outcomes were similar within treatment arms, regardless of the DME duration.Conclusion: Patients with cDME and poor baseline vision who were exposed to low-dose FAc experienced BCVA improvements that were not observed in a similar group from the sham-control arm. These data support the multifactorial pathogenesis of cDME.
0275-004X
1
Chakrav Arthy, Usha
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Yang, Yit
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Lotery, Andrew
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Bailey, Clare
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Ghanchi, Faruque
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Holz, Frank. G
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Downey, Louise
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Weber, Michel
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Eter, Nicole
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Dugel, Pravin, U
e8e3f150-849d-4633-80f4-06df8ae2a6af
Chakrav Arthy, Usha
b12643ac-957e-4543-822f-942738ebcf7b
Yang, Yit
fa4a4f63-34cb-4fb4-8c19-622dc0e4a765
Lotery, Andrew
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Bailey, Clare
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Ghanchi, Faruque
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Holz, Frank. G
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Downey, Louise
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Weber, Michel
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Eter, Nicole
8584fe86-20da-45fe-945c-3bc5fd5ff0d0
Dugel, Pravin, U
e8e3f150-849d-4633-80f4-06df8ae2a6af

Chakrav Arthy, Usha, Yang, Yit, Lotery, Andrew, Bailey, Clare, Ghanchi, Faruque, Holz, Frank. G, Downey, Louise, Weber, Michel, Eter, Nicole and Dugel, Pravin, U (2016) Clinical evidence of the multifactorial nature of diabetic macular edema. Retina, 1. (doi:10.1097/IAE.0000000000001555). (In Press)

Record type: Article

Abstract

Purpose: To report functional and morphologic outcomes, based on diabetic macular edema (DME) chronicity and baseline best-corrected visual acuity (BCVA), from a subanalysis of the fluocinolone acetonide for macular edema (FAME) trials.Methods: Patients were categorized by DME duration (nonchronic [ncDME] or chronic [cDME] DME) and three nonexclusive baseline vision strata. Anatomic and visual acuity VA outcomes of these cohorts were compared with treatment assignment.Results: For all patients with ncDME and cDME who received sham control, 27.8% and 13.4%, respectively, gained >=15 BCVA letters, whereas 22.3% and 34.0% of 0.2 [mu]g/day fluocinolone acetonide (FAc)-treated patients, respectively, gained >=15 BCVA letters. Among patients with ncDME who received sham control, as baseline vision decreased, the percentage gaining >=15 BCVA letters increased; however, among those with cDME, the percentage gaining >=15 BCVA letters did not change as baseline vision decreased. Conversely, among 0.2 [mu]g/day FAc-treated patients, the percentage gaining >=15 BCVA letters increased with decreasing baseline vision, regardless of DME chronicity. Anatomical outcomes were similar within treatment arms, regardless of the DME duration.Conclusion: Patients with cDME and poor baseline vision who were exposed to low-dose FAc experienced BCVA improvements that were not observed in a similar group from the sham-control arm. These data support the multifactorial pathogenesis of cDME.

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Accepted/In Press date: 25 December 2016
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 406733
URI: https://eprints.soton.ac.uk/id/eprint/406733
ISSN: 0275-004X
PURE UUID: 2dc15bbc-adbf-42d8-9f08-0d36b89bea0e
ORCID for Andrew Lotery: ORCID iD orcid.org/0000-0001-5541-4305

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Date deposited: 21 Mar 2017 02:06
Last modified: 10 Dec 2019 01:46

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Contributors

Author: Usha Chakrav Arthy
Author: Yit Yang
Author: Andrew Lotery ORCID iD
Author: Clare Bailey
Author: Faruque Ghanchi
Author: Frank. G Holz
Author: Louise Downey
Author: Michel Weber
Author: Nicole Eter
Author: Pravin, U Dugel

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