Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans

James, E., Chai, J.G., Dewchand, H., Macchiarulo, E., Dazzi, F. and Simpson, E. (2003) Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans. Blood, 102 (1), 388-393. (doi:10.1182/blood-2002-10-3170).

Abstract

One of the factors that increases the risk of graft-versus-host disease following allogeneic stem cell transplantation is the use of multiparous females as donors. Since minor histocompatibility (H) antigens are the main targets of graft-versus-host and graft-versus-leukemia responses, we tested the hypothesis that multiparity could prime minor H antigen—specific T cells.
We examined the peripheral lymphoid populations of multiparous mice and humans for evidence of priming of CD8+ T-cytotoxic lymphocytes against peptide epitopes of the male-specific minor H antigen, HY. In contrast to naive females, multiparous females have measurable levels of circulating HY-specific tetramer-positive T lymphocytes, which can be readily expanded in vitro. These findings have implications for the in vitro generation of T-cell clones as reagents for immunotherapy for tumors following stem cell transplantation.

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Contributors

Author: E. James

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