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Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans

Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans
Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans
One of the factors that increases the risk of graft-versus-host disease following allogeneic stem cell transplantation is the use of multiparous females as donors. Since minor histocompatibility (H) antigens are the main targets of graft-versus-host and graft-versus-leukemia responses, we tested the hypothesis that multiparity could prime minor H antigen—specific T cells.
We examined the peripheral lymphoid populations of multiparous mice and humans for evidence of priming of CD8+ T-cytotoxic lymphocytes against peptide epitopes of the male-specific minor H antigen, HY. In contrast to naive females, multiparous females have measurable levels of circulating HY-specific tetramer-positive T lymphocytes, which can be readily expanded in vitro. These findings have implications for the in vitro generation of T-cell clones as reagents for immunotherapy for tumors following stem cell transplantation.
0006-4971
388-393
James, E.
7dc1afb7-d326-4050-89fc-1f4e2a1a19a4
Chai, J.G.
e8ec8e9a-7165-48a3-be7c-6bbb8ae46f91
Dewchand, H.
51cfacc9-551c-4eb7-ab07-efe9f755d720
Macchiarulo, E.
ed0d395e-5386-4f43-b517-a5129ab04998
Dazzi, F.
7ef9de2e-64dc-4712-8a96-f37b551751ed
Simpson, E.
127514a1-9431-48d2-b3dc-ff871a5e4155
James, E.
7dc1afb7-d326-4050-89fc-1f4e2a1a19a4
Chai, J.G.
e8ec8e9a-7165-48a3-be7c-6bbb8ae46f91
Dewchand, H.
51cfacc9-551c-4eb7-ab07-efe9f755d720
Macchiarulo, E.
ed0d395e-5386-4f43-b517-a5129ab04998
Dazzi, F.
7ef9de2e-64dc-4712-8a96-f37b551751ed
Simpson, E.
127514a1-9431-48d2-b3dc-ff871a5e4155

James, E., Chai, J.G., Dewchand, H., Macchiarulo, E., Dazzi, F. and Simpson, E. (2003) Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans. Blood, 102 (1), 388-393. (doi:10.1182/blood-2002-10-3170).

Record type: Article

Abstract

One of the factors that increases the risk of graft-versus-host disease following allogeneic stem cell transplantation is the use of multiparous females as donors. Since minor histocompatibility (H) antigens are the main targets of graft-versus-host and graft-versus-leukemia responses, we tested the hypothesis that multiparity could prime minor H antigen—specific T cells.
We examined the peripheral lymphoid populations of multiparous mice and humans for evidence of priming of CD8+ T-cytotoxic lymphocytes against peptide epitopes of the male-specific minor H antigen, HY. In contrast to naive females, multiparous females have measurable levels of circulating HY-specific tetramer-positive T lymphocytes, which can be readily expanded in vitro. These findings have implications for the in vitro generation of T-cell clones as reagents for immunotherapy for tumors following stem cell transplantation.

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Published date: 2003

Identifiers

Local EPrints ID: 40677
URI: http://eprints.soton.ac.uk/id/eprint/40677
ISSN: 0006-4971
PURE UUID: 2e14c460-7e57-4705-b8fb-67155bd2f442
ORCID for E. James: ORCID iD orcid.org/0000-0001-8638-7928

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Date deposited: 07 Jul 2006
Last modified: 16 Mar 2024 03:51

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Contributors

Author: E. James ORCID iD
Author: J.G. Chai
Author: H. Dewchand
Author: E. Macchiarulo
Author: F. Dazzi
Author: E. Simpson

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