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SICLOPPS cyclic peptide libraries in drug discovery

SICLOPPS cyclic peptide libraries in drug discovery
SICLOPPS cyclic peptide libraries in drug discovery

Cyclic peptide libraries have demonstrated significant potential when employed against challenging targets such as protein-protein interactions. While a variety of methods for library generation exist, genetically encoded libraries hold several advantages over their chemically synthesized counterparts; they are more readily accessible and allow straightforward hit deconvolution. One method for the intracellular generation of such libraries is split-intein circular ligation of peptides and proteins (SICLOPPS). Here we detail and discuss the deployment of SICLOPPS libraries for the identification of cyclic peptide inhibitors of a variety of targets.

Journal Article, Review
1367-5931
30-35
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2

Tavassoli, Ali (2017) SICLOPPS cyclic peptide libraries in drug discovery. Current Opinion in Chemical Biology, 38, 30-35. (doi:10.1016/j.cbpa.2017.02.016).

Record type: Article

Abstract

Cyclic peptide libraries have demonstrated significant potential when employed against challenging targets such as protein-protein interactions. While a variety of methods for library generation exist, genetically encoded libraries hold several advantages over their chemically synthesized counterparts; they are more readily accessible and allow straightforward hit deconvolution. One method for the intracellular generation of such libraries is split-intein circular ligation of peptides and proteins (SICLOPPS). Here we detail and discuss the deployment of SICLOPPS libraries for the identification of cyclic peptide inhibitors of a variety of targets.

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SICLOPPS review - Accepted Manuscript
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More information

Accepted/In Press date: 16 February 2017
e-pub ahead of print date: 1 March 2017
Published date: June 2017
Keywords: Journal Article, Review
Organisations: CBDT

Identifiers

Local EPrints ID: 406843
URI: http://eprints.soton.ac.uk/id/eprint/406843
ISSN: 1367-5931
PURE UUID: c768bd54-dae3-49ba-86f6-7aa369f96f84
ORCID for Ali Tavassoli: ORCID iD orcid.org/0000-0002-7420-5063

Catalogue record

Date deposited: 24 Mar 2017 02:03
Last modified: 16 Mar 2024 05:09

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