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Microwave therapy for cutaneous human papilloma virus infection

Microwave therapy for cutaneous human papilloma virus infection
Microwave therapy for cutaneous human papilloma virus infection
Human papilloma virus (HPV) infection of keratinocytes causes cutaneous warts. Warts induce significant morbidity and disability but most therapies, including cryotherapy, laser and radiofrequency devices show low efficacy. Microwaves induce heating of tissue in a highly controllable, uniform manner and we set out to explore their use in treatment of HPV.

We present a pilot study of microwave therapy to the skin in 32 individuals with 52 recalcitrant plantar warts. Additionally, we undertook a molecular characterisation of the effects of microwaves on the skin. Microwave therapy was well tolerated and 75.9% of lesions cleared, which compares favourably to 23-33% success for cryotherapy or salicylic acid. Microwaves specifically induced dendritic cell cross-presentation of HPV antigen to CD8+ T-cells in skin and we
show that IL-6 may be important for IRF1 and IRF4 modulation to enhance this process.

Keratinocyte-skin dendritic cell cross-talk is integral to host defence against HPV infections, and this study shows that microwave induces anti-HPV immunity which is important for treatment of warts and potentially HPV-related cancers.
1167-1122
511–518
Bristow, Ian
14af1120-309f-496f-b792-9c1d9d36e791
Lim, Wen Chean
60b7e6ed-1fdb-4de3-b312-75c569726fb5
Lee, Alvin
b22f227e-8d1a-4aea-a897-d0aece6b3dd9
Holbrook, Daniel
903d4d8a-08b1-43fc-bb74-3632b22c5283
Savelyeva, Natalia
804c3e15-d260-4717-9b7c-15c16ba87fc7
Thomson, Peter
cafd9ac7-dcc7-44c2-8237-0c7f48bb147c
Webb, Christopher
60be1016-38ef-478a-873d-0c807c4a5135
Polak, Marta
e0ac5e1a-7074-4776-ba23-490bd4da612d
Ardern-Jones, Michael
7ac43c24-94ab-4d19-ba69-afaa546bec90
Bristow, Ian
14af1120-309f-496f-b792-9c1d9d36e791
Lim, Wen Chean
60b7e6ed-1fdb-4de3-b312-75c569726fb5
Lee, Alvin
b22f227e-8d1a-4aea-a897-d0aece6b3dd9
Holbrook, Daniel
903d4d8a-08b1-43fc-bb74-3632b22c5283
Savelyeva, Natalia
804c3e15-d260-4717-9b7c-15c16ba87fc7
Thomson, Peter
cafd9ac7-dcc7-44c2-8237-0c7f48bb147c
Webb, Christopher
60be1016-38ef-478a-873d-0c807c4a5135
Polak, Marta
e0ac5e1a-7074-4776-ba23-490bd4da612d
Ardern-Jones, Michael
7ac43c24-94ab-4d19-ba69-afaa546bec90

Bristow, Ian, Lim, Wen Chean, Lee, Alvin, Holbrook, Daniel, Savelyeva, Natalia, Thomson, Peter, Webb, Christopher, Polak, Marta and Ardern-Jones, Michael (2017) Microwave therapy for cutaneous human papilloma virus infection. European Journal of Dermatology, 27 (5), 511–518. (doi:10.1684/ejd.2017.3086).

Record type: Article

Abstract

Human papilloma virus (HPV) infection of keratinocytes causes cutaneous warts. Warts induce significant morbidity and disability but most therapies, including cryotherapy, laser and radiofrequency devices show low efficacy. Microwaves induce heating of tissue in a highly controllable, uniform manner and we set out to explore their use in treatment of HPV.

We present a pilot study of microwave therapy to the skin in 32 individuals with 52 recalcitrant plantar warts. Additionally, we undertook a molecular characterisation of the effects of microwaves on the skin. Microwave therapy was well tolerated and 75.9% of lesions cleared, which compares favourably to 23-33% success for cryotherapy or salicylic acid. Microwaves specifically induced dendritic cell cross-presentation of HPV antigen to CD8+ T-cells in skin and we
show that IL-6 may be important for IRF1 and IRF4 modulation to enhance this process.

Keratinocyte-skin dendritic cell cross-talk is integral to host defence against HPV infections, and this study shows that microwave induces anti-HPV immunity which is important for treatment of warts and potentially HPV-related cancers.

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MWforHPV final resp rev PURE upload - Accepted Manuscript
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More information

Accepted/In Press date: 17 March 2017
e-pub ahead of print date: 1 December 2017
Published date: 2017
Organisations: Cancer Sciences, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 406846
URI: https://eprints.soton.ac.uk/id/eprint/406846
ISSN: 1167-1122
PURE UUID: 8c81d4d3-79e0-457a-bb3d-5476eb9a81b0

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Date deposited: 24 Mar 2017 02:04
Last modified: 16 Jul 2019 05:15

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