Laser engineering of three-dimensional (3D) Structures in paper-based microfluidic devices

Abstract

Microfluidic engineering technology has been widely used for implementing lab-on-chip (LOC) type point of care (POC) devices since its origins in the 1990s. LOC devices offer some distinct advantages such as the possibility of reducing the quantity of valuable samples or reagents needed and the shortening of the detection times, both of which result from their compact structure [1]. Paper-based microfluidic devices, which are regarded as a low-cost alternative to conventional POC diagnostics tools, have also been popularly studied in the last few decades, and a huge number of advantages have been explored, such as low-cost, mass production, disposability, being equipment free etc. [2] However, some disadvantages or limitations are also apparent, such as issues with the control of flow rate, multiplexed detection on the same device footprint and further reduction of size [2]. As a result, 3D microfluidic paper analytical devices, as an alternative solution, have been proposed in recent years, which enable distribution of fluids in both lateral and vertical directions.

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Identifiers

ORCID for Ioannis Katis: orcid.org/0000-0002-2016-557X

ORCID for Robert Eason: orcid.org/0000-0001-9704-2204

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