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A story of birth and death: insights into the formation and dynamics of the microglial population

A story of birth and death: insights into the formation and dynamics of the microglial population
A story of birth and death: insights into the formation and dynamics of the microglial population
Microglia are the main resident immunocompetent cells of the brain with key roles in brain development, homeostasis and function. Here we briefly review our current knowledge of the homeostatic mechanisms regulating the composition and turnover of the microglial population under physiological conditions from development to ageing. A greater understanding of these mechanisms may inform understanding of how dysregulation of microglial dynamics could contribute to the pathogenesis and/or progression of neurological disorders.
0889-1591
9-17
Askew, Katharine
ffc96fb4-f94c-4cb7-8479-e9f0b2dae0c7
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Askew, Katharine
ffc96fb4-f94c-4cb7-8479-e9f0b2dae0c7
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5

Askew, Katharine and Gomez-Nicola, Diego (2018) A story of birth and death: insights into the formation and dynamics of the microglial population. Brain, Behavior and Immunity, 69, 9-17. (doi:10.1016/j.bbi.2017.03.009).

Record type: Review

Abstract

Microglia are the main resident immunocompetent cells of the brain with key roles in brain development, homeostasis and function. Here we briefly review our current knowledge of the homeostatic mechanisms regulating the composition and turnover of the microglial population under physiological conditions from development to ageing. A greater understanding of these mechanisms may inform understanding of how dysregulation of microglial dynamics could contribute to the pathogenesis and/or progression of neurological disorders.

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1-s2.0-S0889159117300995-main - Accepted Manuscript
Available under License Creative Commons Attribution Non-commercial No Derivatives.
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Askew & Gomez-Nicola - Version of Record
Available under License Creative Commons Attribution Non-commercial No Derivatives.
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More information

Accepted/In Press date: 20 March 2017
e-pub ahead of print date: 21 March 2017
Published date: March 2018
Organisations: Biomedicine, Centre for Biological Sciences
Learn more about Biological Sciences research

Identifiers

Local EPrints ID: 407413
URI: http://eprints.soton.ac.uk/id/eprint/407413
DOI: doi:10.1016/j.bbi.2017.03.009
ISSN: 0889-1591
PURE UUID: 1f41eba1-ef8f-4bae-8511-882670e8fb70
ORCID for Diego Gomez-Nicola: ORCID iD orcid.org/0000-0002-5316-2682

Catalogue record

Date deposited: 05 Apr 2017 01:10
Last modified: 16 Mar 2024 05:11

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Contributors

Author: Katharine Askew
Author: Diego Gomez-Nicola ORCID iD

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