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A story of birth and death: insights into the formation and dynamics of the microglial population

A story of birth and death: insights into the formation and dynamics of the microglial population
A story of birth and death: insights into the formation and dynamics of the microglial population
Microglia are the main resident immunocompetent cells of the brain with key roles in brain development, homeostasis and function. Here we briefly review our current knowledge of the homeostatic mechanisms regulating the composition and turnover of the microglial population under physiological conditions from development to ageing. A greater understanding of these mechanisms may inform understanding of how dysregulation of microglial dynamics could contribute to the pathogenesis and/or progression of neurological disorders.
0889-1591
Askew, Katharine
ffc96fb4-f94c-4cb7-8479-e9f0b2dae0c7
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Askew, Katharine and Gomez-Nicola, Diego (2017) A story of birth and death: insights into the formation and dynamics of the microglial population Brain, Behavior and Immunity (doi:10.1016/j.bbi.2017.03.009).

Askew, Katharine and Gomez-Nicola, Diego (2017) A story of birth and death: insights into the formation and dynamics of the microglial population Brain, Behavior and Immunity (doi:10.1016/j.bbi.2017.03.009).

Record type: Article

Abstract

Microglia are the main resident immunocompetent cells of the brain with key roles in brain development, homeostasis and function. Here we briefly review our current knowledge of the homeostatic mechanisms regulating the composition and turnover of the microglial population under physiological conditions from development to ageing. A greater understanding of these mechanisms may inform understanding of how dysregulation of microglial dynamics could contribute to the pathogenesis and/or progression of neurological disorders.

Text 1-s2.0-S0889159117300995-main - Accepted Manuscript
Restricted to Repository staff only until 21 March 2018.
Text Askew & Gomez-Nicola - Version of Record
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More information

Accepted/In Press date: 20 March 2017
e-pub ahead of print date: 21 March 2017
Organisations: Biomedicine, Centre for Biological Sciences

Identifiers

Local EPrints ID: 407413
URI: http://eprints.soton.ac.uk/id/eprint/407413
ISSN: 0889-1591
PURE UUID: 1f41eba1-ef8f-4bae-8511-882670e8fb70
ORCID for Diego Gomez-Nicola: ORCID iD orcid.org/0000-0002-5316-2682

Catalogue record

Date deposited: 05 Apr 2017 01:10
Last modified: 17 Oct 2017 16:31

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