Which sites react first? Functional site distribution and kinetics on solid supports investigated using confocal Raman and fluorescence microscopy
Which sites react first? Functional site distribution and kinetics on solid supports investigated using confocal Raman and fluorescence microscopy
Fluorescence microscopy is a powerful technique for analyzing beads with very low loadings of fluorophores; however, the method is flawed when looking at more highly loaded beads as a result of severe problems with absorption. To probe distributions at higher loading levels, Raman spectroscopy avoids many of these issues. These studies show that there is a uniform distribution of reactive sites throughout the beads but that the spatial distribution of reacted sites depends on the polymer type, with a fine balance between reaction and diffusion rate.
combinatorial chemistry, organic-synthesis, resin beads, phase, microspectroscopy, polystyrene
28-32
Kress, J.
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Zanaletti, R.
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Rose, A.
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Frey, J.G.
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Brocklesby, W.S.
c53ca2f6-db65-4e19-ad00-eebeb2e6de67
Ladlow, M.
382f57de-d703-44ab-847f-141b7f760119
Bradley, M.
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February 2003
Kress, J.
08d8c204-6c80-410b-9d90-45ca029d4736
Zanaletti, R.
7e8e5945-ecea-4a2f-8c04-4223d5429fc2
Rose, A.
44dd032a-db31-411c-a86b-142829cba58f
Frey, J.G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Brocklesby, W.S.
c53ca2f6-db65-4e19-ad00-eebeb2e6de67
Ladlow, M.
382f57de-d703-44ab-847f-141b7f760119
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
Kress, J., Zanaletti, R., Rose, A., Frey, J.G., Brocklesby, W.S., Ladlow, M. and Bradley, M.
(2003)
Which sites react first? Functional site distribution and kinetics on solid supports investigated using confocal Raman and fluorescence microscopy.
Journal of Combinatorial Chemistry, 5 (1), .
(doi:10.1021/cc020024x).
Abstract
Fluorescence microscopy is a powerful technique for analyzing beads with very low loadings of fluorophores; however, the method is flawed when looking at more highly loaded beads as a result of severe problems with absorption. To probe distributions at higher loading levels, Raman spectroscopy avoids many of these issues. These studies show that there is a uniform distribution of reactive sites throughout the beads but that the spatial distribution of reacted sites depends on the polymer type, with a fine balance between reaction and diffusion rate.
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Published date: February 2003
Keywords:
combinatorial chemistry, organic-synthesis, resin beads, phase, microspectroscopy, polystyrene
Identifiers
Local EPrints ID: 40750
URI: http://eprints.soton.ac.uk/id/eprint/40750
ISSN: 1520-4766
PURE UUID: a75c1fb7-2632-44d1-a3a5-cb9c2766ce46
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Date deposited: 07 Jul 2006
Last modified: 16 Mar 2024 02:39
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Contributors
Author:
J. Kress
Author:
R. Zanaletti
Author:
A. Rose
Author:
M. Ladlow
Author:
M. Bradley
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