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Which sites react first? Functional site distribution and kinetics on solid supports investigated using confocal Raman and fluorescence microscopy

Which sites react first? Functional site distribution and kinetics on solid supports investigated using confocal Raman and fluorescence microscopy
Which sites react first? Functional site distribution and kinetics on solid supports investigated using confocal Raman and fluorescence microscopy
Fluorescence microscopy is a powerful technique for analyzing beads with very low loadings of fluorophores; however, the method is flawed when looking at more highly loaded beads as a result of severe problems with absorption. To probe distributions at higher loading levels, Raman spectroscopy avoids many of these issues. These studies show that there is a uniform distribution of reactive sites throughout the beads but that the spatial distribution of reacted sites depends on the polymer type, with a fine balance between reaction and diffusion rate.
combinatorial chemistry, organic-synthesis, resin beads, phase, microspectroscopy, polystyrene
1520-4766
28-32
Kress, J.
08d8c204-6c80-410b-9d90-45ca029d4736
Zanaletti, R.
7e8e5945-ecea-4a2f-8c04-4223d5429fc2
Rose, A.
44dd032a-db31-411c-a86b-142829cba58f
Frey, J.G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Brocklesby, W.S.
c53ca2f6-db65-4e19-ad00-eebeb2e6de67
Ladlow, M.
382f57de-d703-44ab-847f-141b7f760119
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
Kress, J.
08d8c204-6c80-410b-9d90-45ca029d4736
Zanaletti, R.
7e8e5945-ecea-4a2f-8c04-4223d5429fc2
Rose, A.
44dd032a-db31-411c-a86b-142829cba58f
Frey, J.G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Brocklesby, W.S.
c53ca2f6-db65-4e19-ad00-eebeb2e6de67
Ladlow, M.
382f57de-d703-44ab-847f-141b7f760119
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d

Kress, J., Zanaletti, R., Rose, A., Frey, J.G., Brocklesby, W.S., Ladlow, M. and Bradley, M. (2003) Which sites react first? Functional site distribution and kinetics on solid supports investigated using confocal Raman and fluorescence microscopy. Journal of Combinatorial Chemistry, 5 (1), 28-32. (doi:10.1021/cc020024x).

Record type: Article

Abstract

Fluorescence microscopy is a powerful technique for analyzing beads with very low loadings of fluorophores; however, the method is flawed when looking at more highly loaded beads as a result of severe problems with absorption. To probe distributions at higher loading levels, Raman spectroscopy avoids many of these issues. These studies show that there is a uniform distribution of reactive sites throughout the beads but that the spatial distribution of reacted sites depends on the polymer type, with a fine balance between reaction and diffusion rate.

Full text not available from this repository.

More information

Published date: February 2003
Keywords: combinatorial chemistry, organic-synthesis, resin beads, phase, microspectroscopy, polystyrene

Identifiers

Local EPrints ID: 40750
URI: http://eprints.soton.ac.uk/id/eprint/40750
ISSN: 1520-4766
PURE UUID: a75c1fb7-2632-44d1-a3a5-cb9c2766ce46
ORCID for J.G. Frey: ORCID iD orcid.org/0000-0003-0842-4302
ORCID for W.S. Brocklesby: ORCID iD orcid.org/0000-0002-2123-6712

Catalogue record

Date deposited: 07 Jul 2006
Last modified: 17 Dec 2019 02:04

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