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Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety

Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety
Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety
Background: The impact of combined variants of Oxytocin Receptor (OXTR) and G protein β3 subunit genes was investigated in relation to retrospective reports of childhood as well as contemporary adult separation anxiety (SA), based on evidence of a β/γ dimer-mediated signaling for OXTR.

Methods: A case-control association study (225 healthy adults and 188 outpatients with depression) was performed to establish Risk-Combined Genotype (RCG) of the studied variants (OXTR rs53576 and the functional Gβ3 subunit rs5443). Current SA was evaluated by the ASA-27 and retrospective childhood symptoms by the SASI. GG genotype of OXTR rs53576 combined with T-carrier genotype of Gβ3 rs5443 represented the RCG.

Results: Compared to non-RCG, those with RCG had significantly higher levels of childhood and adult SA. The RCG was significantly associated with childhood SA threshold score (OR=2.85, 90%CI: 1.08–7.50). Childhood SA was, in turn, strongly associated with a threshold SA score in adulthood (OR= 15.58; 95% CI: 4.62–52.59).

Limitations: Although the overall sample size is sizable, comparisons among subgroups with specific combination of alleles are based on relatively small numbers.

Conclusions: Our study indicates that variations in OXTR and Gβ3 genes are specifically associated with presence and severity of SA in childhood and adulthood, but not with depression or anxiety in general. Because there is increasing interest in oxytocin in social behavior, the gene-SA associations identified have potential translational and clinical relevance.
separation anxiety, oxytocin receptor, Gβ3, depression, polymorphisms
Costa, Barbara
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Pini, Stefano
d2917a4b-e216-404e-aaff-1c9f5ecb202d
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Silove, Derrick
7659224c-8d6f-4415-9262-b5c0f7574ea2
Manicavasagar, Vijaya
d1268b1c-8e09-43df-9305-10a02ee8b3d1
Abelli, Marianna
b762b8e8-5fce-4217-a538-7355bf443975
Coppedè, Fabio
1f57631f-987f-4d3e-987e-2efafe10e095
Martini, Claudia
647490d0-d823-4c06-9c19-e5224adfb433
Costa, Barbara
29f19721-0ba0-4b9c-bdda-ba9611cd912c
Pini, Stefano
d2917a4b-e216-404e-aaff-1c9f5ecb202d
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Silove, Derrick
7659224c-8d6f-4415-9262-b5c0f7574ea2
Manicavasagar, Vijaya
d1268b1c-8e09-43df-9305-10a02ee8b3d1
Abelli, Marianna
b762b8e8-5fce-4217-a538-7355bf443975
Coppedè, Fabio
1f57631f-987f-4d3e-987e-2efafe10e095
Martini, Claudia
647490d0-d823-4c06-9c19-e5224adfb433

Costa, Barbara, Pini, Stefano, Baldwin, David S., Silove, Derrick, Manicavasagar, Vijaya, Abelli, Marianna, Coppedè, Fabio and Martini, Claudia (2017) Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety. Journal of Affective Disorders. (doi:10.1016/j.jad.2017.03.056).

Record type: Article

Abstract

Background: The impact of combined variants of Oxytocin Receptor (OXTR) and G protein β3 subunit genes was investigated in relation to retrospective reports of childhood as well as contemporary adult separation anxiety (SA), based on evidence of a β/γ dimer-mediated signaling for OXTR.

Methods: A case-control association study (225 healthy adults and 188 outpatients with depression) was performed to establish Risk-Combined Genotype (RCG) of the studied variants (OXTR rs53576 and the functional Gβ3 subunit rs5443). Current SA was evaluated by the ASA-27 and retrospective childhood symptoms by the SASI. GG genotype of OXTR rs53576 combined with T-carrier genotype of Gβ3 rs5443 represented the RCG.

Results: Compared to non-RCG, those with RCG had significantly higher levels of childhood and adult SA. The RCG was significantly associated with childhood SA threshold score (OR=2.85, 90%CI: 1.08–7.50). Childhood SA was, in turn, strongly associated with a threshold SA score in adulthood (OR= 15.58; 95% CI: 4.62–52.59).

Limitations: Although the overall sample size is sizable, comparisons among subgroups with specific combination of alleles are based on relatively small numbers.

Conclusions: Our study indicates that variations in OXTR and Gβ3 genes are specifically associated with presence and severity of SA in childhood and adulthood, but not with depression or anxiety in general. Because there is increasing interest in oxytocin in social behavior, the gene-SA associations identified have potential translational and clinical relevance.

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1-s2.0-S0165032716316263-main - Accepted Manuscript
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More information

Accepted/In Press date: 26 March 2017
e-pub ahead of print date: 27 March 2017
Keywords: separation anxiety, oxytocin receptor, Gβ3, depression, polymorphisms
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 407529
URI: https://eprints.soton.ac.uk/id/eprint/407529
PURE UUID: 0fafe564-aad5-4ee3-a93a-0bc685325d9c

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Date deposited: 13 Apr 2017 01:05
Last modified: 10 Dec 2019 06:05

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