Etiology of acute diarrhea in the elderly in China: a six-year observational study
Etiology of acute diarrhea in the elderly in China: a six-year observational study
Acute diarrhea leads to a substantial disease burden among the elderly worldwide. However, in the context of increasingly aging trend in China, the prevalence of etiological agents among elderly diarrheal patients was undetermined. This study aimed to explore the major enteropathogens of acute diarrhea among outpatients older than 65 years in China, and also the epidemiological features of the pathogens. Demographic and clinical data for acute diarrhea among outpatients older than 65 years were collected from 213 participating hospitals from 2009 to 2014. Stool specimens were collected and tested for 13 enteric viruses and bacteria. The proportion of outpatients positive for targeted pathogens was analyzed by residential areas and seasonal patterns. Among the 7,725 patients enrolled, 1,617 (20.9%)were positive for any one of the 13 study pathogens. The predominant pathogen was norovirus (9.0%), followed by diarrheagenic Escherichia coli (DEC) (5.5%), rotavirus (3.9%), non-typhoidal Salmonella (NTS) (2.9%), and Shigella spp. (2.5%). The prevalence of Shigella spp. among rural patients (6.9%) was higher than that among urban patients (1.6%) (p < 0.001), with opposite trend for DEC (3.6% versus 5.9%, p = 0.007). An obvious seasonal pattern was observed for major pathogens, with peak for norovirus in autumn, rotavirus in winter and DEC, NTS, and Shigella spp. in summer. A wide variety of enteropathogens were detected among the elderly with acute diarrhea in China, with norovirus and DEC being the most commonly isolated pathogens. A strong seasonal pattern was observed for major pathogens of acute diarrhea among the elderly.
Journal Article
e0173881
Zhang, Zike
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Lai, Shengjie
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Yu, Jianxing
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Geng, Qibin
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Yang, Wanqi
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Chen, Yu
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Wu, Jianguo
ac62a636-3c48-4a39-8eb2-04156a2b4409
Jing, Huaiqi
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Yang, Weizhong
65d18fbc-d752-42a7-ac38-01534ceda15c
Li, Zhongjie
f89a98f7-f6d3-4312-995a-bc658ae9a93f
21 March 2017
Zhang, Zike
85c05276-59dd-4033-82c9-4d33e872906b
Lai, Shengjie
b57a5fe8-cfb6-4fa7-b414-a98bb891b001
Yu, Jianxing
992198dd-6055-4905-ab28-11ced790c57c
Geng, Qibin
8c0f930c-f49f-40df-b954-fddd27eb9a76
Yang, Wanqi
a69b513f-41ba-4e24-8861-41914425037f
Chen, Yu
b7c530d5-7aa6-4515-ac71-907f6673423b
Wu, Jianguo
ac62a636-3c48-4a39-8eb2-04156a2b4409
Jing, Huaiqi
58ab0211-3a7f-41a6-9dd1-8763f3228ee4
Yang, Weizhong
65d18fbc-d752-42a7-ac38-01534ceda15c
Li, Zhongjie
f89a98f7-f6d3-4312-995a-bc658ae9a93f
Zhang, Zike, Lai, Shengjie, Yu, Jianxing, Geng, Qibin, Yang, Wanqi, Chen, Yu, Wu, Jianguo, Jing, Huaiqi, Yang, Weizhong and Li, Zhongjie
(2017)
Etiology of acute diarrhea in the elderly in China: a six-year observational study.
PLoS ONE, 12 (3), .
(doi:10.1371/journal.pone.0173881).
Abstract
Acute diarrhea leads to a substantial disease burden among the elderly worldwide. However, in the context of increasingly aging trend in China, the prevalence of etiological agents among elderly diarrheal patients was undetermined. This study aimed to explore the major enteropathogens of acute diarrhea among outpatients older than 65 years in China, and also the epidemiological features of the pathogens. Demographic and clinical data for acute diarrhea among outpatients older than 65 years were collected from 213 participating hospitals from 2009 to 2014. Stool specimens were collected and tested for 13 enteric viruses and bacteria. The proportion of outpatients positive for targeted pathogens was analyzed by residential areas and seasonal patterns. Among the 7,725 patients enrolled, 1,617 (20.9%)were positive for any one of the 13 study pathogens. The predominant pathogen was norovirus (9.0%), followed by diarrheagenic Escherichia coli (DEC) (5.5%), rotavirus (3.9%), non-typhoidal Salmonella (NTS) (2.9%), and Shigella spp. (2.5%). The prevalence of Shigella spp. among rural patients (6.9%) was higher than that among urban patients (1.6%) (p < 0.001), with opposite trend for DEC (3.6% versus 5.9%, p = 0.007). An obvious seasonal pattern was observed for major pathogens, with peak for norovirus in autumn, rotavirus in winter and DEC, NTS, and Shigella spp. in summer. A wide variety of enteropathogens were detected among the elderly with acute diarrhea in China, with norovirus and DEC being the most commonly isolated pathogens. A strong seasonal pattern was observed for major pathogens of acute diarrhea among the elderly.
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journal.pone.0173881
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Accepted/In Press date: 28 February 2017
e-pub ahead of print date: 21 March 2017
Published date: 21 March 2017
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Journal Article
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Local EPrints ID: 407591
URI: http://eprints.soton.ac.uk/id/eprint/407591
ISSN: 1932-6203
PURE UUID: 99636caf-07ea-4afd-8d76-353f872ab3e5
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Date deposited: 16 Apr 2017 16:59
Last modified: 16 Mar 2024 04:36
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Author:
Zike Zhang
Author:
Jianxing Yu
Author:
Qibin Geng
Author:
Wanqi Yang
Author:
Yu Chen
Author:
Jianguo Wu
Author:
Huaiqi Jing
Author:
Weizhong Yang
Author:
Zhongjie Li
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