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Under-five mortality according to maternal survival: a systematic review and meta-analysis

Under-five mortality according to maternal survival: a systematic review and meta-analysis
Under-five mortality according to maternal survival: a systematic review and meta-analysis
Objective: To investigate, within so-called general populations, the relationship between maternal survival and mortality of children younger than five years.

Methods: We conducted a systematic review of literature published between January 1990 and November 2016 that reported maternal vital status and the corresponding mortality of children younger than five years. Seven studies were included in a qualitative analysis and four in a random-effects meta-analysis. Summary estimates of the odds of dying by maternal survival were obtained and statistical heterogeneity estimated. Quality of the included studies and evidence was assessed using a Cochrane tool for assessing risk of bias and the Grading of Recommendations Assessment, Development and Evaluation criteria, respectively.

Findings: Among children younger than five years, those whose mother had died were found to be 4.09 times (95% confidence interval, CI: 2.40–6.98) more likely to die than those with surviving mothers. Due to heterogeneity (I2: 83%), further pooled estimates were not possible. For children that were motherless as a result of maternal mortality, the increased odds of dying ranged from 1.40 (95% CI: 0.47–4.21) to 2.92 (95% CI: 1.21–7.04) among those aged between two and four years, 6.1 (95% CI: 2.27–16.77) to 33.78 (95% CI: 24.21–47.14) for those younger than one year and 4.39 (95% CI: 3.34–5.78) to 51.68 (95% CI: 20.26–131.80) for those younger than six months.

Conclusion: The loss of a mother was associated with increased mortality among children, especially when maternal death occurred in the first year of the child’s life.
0042-9686
281-287
Chikhungu, Lana Clara
db8d9e7a-183e-49aa-aa84-0ff3f0cbb86d
Newell, Marie-Louise
c6ff99dd-c23b-4fef-a846-a221fe2522b3
Rollins, Nigel
79b9cfdb-4a6b-44c1-89d9-dbe948a09167
Chikhungu, Lana Clara
db8d9e7a-183e-49aa-aa84-0ff3f0cbb86d
Newell, Marie-Louise
c6ff99dd-c23b-4fef-a846-a221fe2522b3
Rollins, Nigel
79b9cfdb-4a6b-44c1-89d9-dbe948a09167

Chikhungu, Lana Clara, Newell, Marie-Louise and Rollins, Nigel (2017) Under-five mortality according to maternal survival: a systematic review and meta-analysis. Bulletin of the World Health Organization, 95 (4), 281-287. (doi:10.2471/BLT.15.157149).

Record type: Article

Abstract

Objective: To investigate, within so-called general populations, the relationship between maternal survival and mortality of children younger than five years.

Methods: We conducted a systematic review of literature published between January 1990 and November 2016 that reported maternal vital status and the corresponding mortality of children younger than five years. Seven studies were included in a qualitative analysis and four in a random-effects meta-analysis. Summary estimates of the odds of dying by maternal survival were obtained and statistical heterogeneity estimated. Quality of the included studies and evidence was assessed using a Cochrane tool for assessing risk of bias and the Grading of Recommendations Assessment, Development and Evaluation criteria, respectively.

Findings: Among children younger than five years, those whose mother had died were found to be 4.09 times (95% confidence interval, CI: 2.40–6.98) more likely to die than those with surviving mothers. Due to heterogeneity (I2: 83%), further pooled estimates were not possible. For children that were motherless as a result of maternal mortality, the increased odds of dying ranged from 1.40 (95% CI: 0.47–4.21) to 2.92 (95% CI: 1.21–7.04) among those aged between two and four years, 6.1 (95% CI: 2.27–16.77) to 33.78 (95% CI: 24.21–47.14) for those younger than one year and 4.39 (95% CI: 3.34–5.78) to 51.68 (95% CI: 20.26–131.80) for those younger than six months.

Conclusion: The loss of a mother was associated with increased mortality among children, especially when maternal death occurred in the first year of the child’s life.

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Lana mortality paper systematic review WHO Bulleting April 2017 - Version of Record
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More information

Accepted/In Press date: 3 December 2016
e-pub ahead of print date: 2 February 2017
Published date: April 2017
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 407782
URI: https://eprints.soton.ac.uk/id/eprint/407782
ISSN: 0042-9686
PURE UUID: 63d599a2-d5ba-4ca5-ab6a-2b26e17b5a8c
ORCID for Marie-Louise Newell: ORCID iD orcid.org/0000-0002-1074-7699

Catalogue record

Date deposited: 26 Apr 2017 01:06
Last modified: 20 Jul 2019 00:38

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