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Regulation of Listeria virulence: PrfA master and commander

Regulation of Listeria virulence: PrfA master and commander
Regulation of Listeria virulence: PrfA master and commander

Listeria monocytogenes is the causative agent of listeriosis, a severe foodborne infection. These bacteria live as soil saprotrophs on decaying plant matter but also as intracellular parasites, using the cell cytosol as a replication niche. PrfA, a regulatory protein, integrates a number of environmental cues that signal the transition between these two contrasting lifestyles, activating a set of key virulence factors during host infection. While a number of details concerning the general mode of action of this virulence master switch have been elucidated, others remain unsolved. Recent work has revealed additional mechanisms that contribute to L. monocytogenes virulence modulation, often via cross-talk with PrfA, or by regulating new genes involved in host colonization.

1369-5274
118-127
de las Heras, Aitor
f683308c-b28d-4848-a8f0-1f7a7cf247a7
Cain, Robert J.
07972451-2682-4daa-afe9-8582efc64a8f
Bielecka, Magdalena K.
90391ea3-aa1f-4104-a893-568c138718a2
Vázquez-Boland, José A.
53433537-838b-433e-b1ee-f8648f9b2b26
de las Heras, Aitor
f683308c-b28d-4848-a8f0-1f7a7cf247a7
Cain, Robert J.
07972451-2682-4daa-afe9-8582efc64a8f
Bielecka, Magdalena K.
90391ea3-aa1f-4104-a893-568c138718a2
Vázquez-Boland, José A.
53433537-838b-433e-b1ee-f8648f9b2b26

de las Heras, Aitor, Cain, Robert J., Bielecka, Magdalena K. and Vázquez-Boland, José A. (2011) Regulation of Listeria virulence: PrfA master and commander. Current Opinion in Microbiology, 14 (2), 118-127. (doi:10.1016/j.mib.2011.01.005).

Record type: Review

Abstract

Listeria monocytogenes is the causative agent of listeriosis, a severe foodborne infection. These bacteria live as soil saprotrophs on decaying plant matter but also as intracellular parasites, using the cell cytosol as a replication niche. PrfA, a regulatory protein, integrates a number of environmental cues that signal the transition between these two contrasting lifestyles, activating a set of key virulence factors during host infection. While a number of details concerning the general mode of action of this virulence master switch have been elucidated, others remain unsolved. Recent work has revealed additional mechanisms that contribute to L. monocytogenes virulence modulation, often via cross-talk with PrfA, or by regulating new genes involved in host colonization.

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More information

e-pub ahead of print date: 8 March 2011
Published date: April 2011
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 408003
URI: http://eprints.soton.ac.uk/id/eprint/408003
ISSN: 1369-5274
PURE UUID: ab0a599e-147a-4e17-b0ce-f8837ba6c9f3

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Date deposited: 06 May 2017 01:06
Last modified: 15 Mar 2024 13:24

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Contributors

Author: Aitor de las Heras
Author: Robert J. Cain
Author: Magdalena K. Bielecka
Author: José A. Vázquez-Boland

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