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Growth factor profiles in intraperitoneal drainage fluid following colorectal surgery: relationship to wound healing and surgery

Baker, Elizabeth A., El-Gaddal, Sanaa, Aitken, Douglas G. and Leaper, David J. (2003) Growth factor profiles in intraperitoneal drainage fluid following colorectal surgery: relationship to wound healing and surgery Wound Repair and Regeneration, 11, (4), pp. 261-267. (doi:10.1046/j.1524-475X.2003.11405.x).

Record type: Article


Cytokines and growth factors are important at each stage of wound healing. This study aims to determine the changing profiles of these factors in intraperitoneal drainage, acute wound fluid, following colorectal surgery, and to correlate levels to wound healing and surgical outcomes. Acute wound fluid samples (n = 52 patients) were collected daily from postoperative day 1 until drain removal. Levels of cytokines (interleukins-6 and -1? and tumor necrosis factor-?) and epidermal growth factor, platelet-derived growth factor, vascular endothelial derived growth factor, basic fibroblast growth factor, and transforming growth factor-?1 were determined by enzyme-linked immunosorbent assay. A significant negative correlation emerged between the levels of interleukin-6, epidermal growth factor, platelet-derived growth factor, and basic fibroblast growth factor and the postoperative day, e.g., basic fibroblast growth factor : day 1, 695, median (29–2,806, range) pg/ml; day 2, 249 (1–1,784); day 3, 94 (0–722); day 7, 22 (0–326) (p < 0.05, Spearman's correlation). Levels appeared to relate to the stage of wound healing. Several factors, in particular interleukin-1? and tumor necrosis factor-? levels, correlated with surgical outcomes such as the need for a defunctioning stoma and/or postoperative complications. Cytokines and growth factors are involved in normal wound healing, and their levels in acute wound fluid may act as markers of wound healing and surgical outcome.

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Published date: July 2003
Keywords: wound healing, intraperitoneal drainage, colorectal surgery, surgical wounds


Local EPrints ID: 40824
ISSN: 1067-1927
PURE UUID: 690e8d3c-cb30-4079-95fa-1ae1d4ea01d3

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Date deposited: 10 Jul 2006
Last modified: 17 Jul 2017 15:33

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Author: Elizabeth A. Baker
Author: Sanaa El-Gaddal
Author: Douglas G. Aitken
Author: David J. Leaper

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