Chromogranins A and B and secretogranin II: evolutionary and functional aspects
Chromogranins A and B and secretogranin II: evolutionary and functional aspects
Chromogranins/secretogranins or granins are a class of acidic, secretory proteins that occur in endocrine, neuroendocrine, and neuronal cells. Granins are the precursors of several bioactive peptides and may be involved in secretory granule formation and neurotransmitter/hormone release. Characterization and analysis of chromogranin A (CgA), chromogranin B (CgB), and secretogranin II (SgII) in distant vertebrate species confirmed that CgA and CgB belong to related monophyletic groups, probably evolving from a common ancestral precursor, while SgII sequences constitute a distinct monophyletic group. In particular, selective sequences within these proteins, bounded by potential processing sites, have been remarkably conserved during evolution. Peptides named vasostatin, secretolytin and secretoneurin, which occur in these regions, have been shown to exert various biological activities. These conserved domains may also be involved in the formation of secretory granules in different vertebrates. Other peptides such as catestatin and pancreastatin may have appeared late during evolution. The function of granins as propeptide precursors and granulogenic factors is discussed in the light of recent data obtained in various model species and using knockout mice strains.
309–324
Elias, Salah
a9b11116-8efb-44b3-8241-2f0f2af847c3
February 2008
Elias, Salah
a9b11116-8efb-44b3-8241-2f0f2af847c3
Elias, Salah
(2008)
Chromogranins A and B and secretogranin II: evolutionary and functional aspects.
Acta Physiologica Scandinavica, 192 (2), .
(doi:10.1111/j.1748-1716.2007.01806.x).
Abstract
Chromogranins/secretogranins or granins are a class of acidic, secretory proteins that occur in endocrine, neuroendocrine, and neuronal cells. Granins are the precursors of several bioactive peptides and may be involved in secretory granule formation and neurotransmitter/hormone release. Characterization and analysis of chromogranin A (CgA), chromogranin B (CgB), and secretogranin II (SgII) in distant vertebrate species confirmed that CgA and CgB belong to related monophyletic groups, probably evolving from a common ancestral precursor, while SgII sequences constitute a distinct monophyletic group. In particular, selective sequences within these proteins, bounded by potential processing sites, have been remarkably conserved during evolution. Peptides named vasostatin, secretolytin and secretoneurin, which occur in these regions, have been shown to exert various biological activities. These conserved domains may also be involved in the formation of secretory granules in different vertebrates. Other peptides such as catestatin and pancreastatin may have appeared late during evolution. The function of granins as propeptide precursors and granulogenic factors is discussed in the light of recent data obtained in various model species and using knockout mice strains.
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e-pub ahead of print date: 15 November 2007
Published date: February 2008
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Biomedicine
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Local EPrints ID: 408241
URI: http://eprints.soton.ac.uk/id/eprint/408241
PURE UUID: 2d95bfa0-5c14-4204-8725-edf51eb33989
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Date deposited: 18 May 2017 04:01
Last modified: 16 Mar 2024 04:29
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